Results 161 to 170 of about 10,513,270 (364)

Exponential Communication Separations between Notions of Selfishness [PDF]

arXiv, 2020
We consider the problem of implementing a fixed social choice function between multiple players (which takes as input a type $t_i$ from each player $i$ and outputs an outcome $f(t_1,\ldots, t_n)$), in which each player must be incentivized to follow the protocol. In particular, we study the communication requirements of a protocol which: (a) implements
arxiv  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Optimal Reduction without Oracle? [PDF]

arXiv, 2017
We suggest an approach to solve the problem of matching fans in interaction net implementations of optimal reduction for the pure untyped lambda calculus without use of any additional agent types. Our implementation supports a wider class of lambda terms than the abstract version of Lamping's algorithm and beats the interaction net implementation of ...
arxiv  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Methodology Issues in Implementation Science

Medical Care, 2013
Putting evidence into practice at the point of care delivery requires an understanding of implementation strategies that work, in what context and how.To identify methodological issues in implementation science using 4 studies as cases and make recommendations for further methods development.Four cases are presented and methodological issues identified.
Newhouse, Robin, Bobay, Kathleen, Dykes, Patricia C., Stevens, Kathleen R., Titler, Marita   +4 more
openaire   +4 more sources

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Perceived Risk for Severe COVID-19 and Oral Antiviral Use Among Antiviral-Eligible US Adults

Infectious Diseases and Therapy
Introduction Oral antiviral medications are important tools for preventing severe COVID-19 outcomes. However, their uptake remains low for reasons that are not entirely understood.
Kate Penrose, Avantika Srivastava, Yanhan Shen, McKaylee M. Robertson, Sarah G. Kulkarni, Kristen E. Allen, Thomas M. Porter, Laura Puzniak, John M. McLaughlin, Denis Nash   +9 more
doaj   +1 more source

Re-energising the way we manage change in healthcare: the case for soft systems methodology and its application to evidence-based practice

BMC Health Services Research, 2019
Background Updating, improving and spreading the evidence base for healthcare practices has proven to be a challenge of considerable magnitude – a wicked, multi-dimensional problem.
Hanna Augustsson, Kate Churruca, Jeffrey Braithwaite   +2 more
doaj   +1 more source

Symbolic Synthesis of Knowledge-based Program Implementations with Synchronous Semantics [PDF]

arXiv, 2013
This paper deals with the automated synthesis of implementations of knowledge-based programs with respect to two synchronous semantics (clock and synchronous perfect recall). An approach to the synthesis problem based on the use of symbolic representations is described. The method has been implemented as an extension to the model checker MCK.
arxiv