Results 101 to 110 of about 9,087,892 (300)

Integration and evaluation of implementation strategies to improve guideline-concordant bladder cancer surveillance: a prospective observational study [PDF]

Background: Despite guideline recommendations, our prior work revealed more than half of low-risk bladder cancer patients within the Department of Veterans Affairs (VA) undergo too many surveillance procedures and about a third of high-risk patients do ...
Ould Ismail, A. Aziz, Zubkoff, Lisa, Jensen, Laura, Kimball, Elisabeth R., Bloomquist, Kennedi, Schroeck, Florian R., Haggstrom, David A., Kale, Soham, Issa, Muta M., Siddiqui, Mohummad Minhaj, Tosoian, Jeffrey J., Zickmund, Susan   +11 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Summary of REFOCUS implementation strategies.

, 2014
Summary of REFOCUS implementation strategies.
Mary Leamy (569525), Genevieve Riley (569531), Mike Slade (569532), Julie Williams (110407), Monika Janosik (569529), Kai Sabas (569530), Victoria Bird (569528), Eleanor Clarke (569526), Clair Le Boutillier (569527)   +8 more
core   +1 more source

Advancing and strengthening the study of social networks in community-level dissemination and implementation research: A narrative review

Journal of Clinical and Translational Science
The dissemination and implementation (D&I) of evidence at the community level is critical to improve health and advance health equity. Social networks are considered essential to D&I efforts, but there lacks clarity regarding how best to study and ...
Ariella R. Korn, Jennifer L. Cruz, Natalie R. Smith, Rebekah R. Jacob, Megan Carney, Wallis Slater, Shoba Ramanadhan   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Empirical Conclusion from the Managerial Perception for the Various Multi-Brands Strategies and their Implementations [PDF]

This study enumerates the implicit conclusions (i.e. rank/ importance of multi brand strategies) which are drawn from the managerial perception for various multi-brand strategies while interrogating the impact of such conclusions on the level of ...
Subhani, Muhammad Imtiaz, Hasan, Syed Akif   +1 more
core  

International Atherosclerosis Society Roadmap for Familial Hypercholesterolaemia

Global Heart
Familial hypercholesterolaemia (FH), a common monogenic disorder, is a preventable cause of premature coronary artery disease and death. Up to 35 million people worldwide have FH, but most remain undetected and undertreated.
Gerald F. Watts, Laney K. Jones, Mitchell N. Sarkies, Jing Pang, Samuel S. Gidding, Peter Libby, Raul D. Santos   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Systematic review of implementation strategies for risk tables in the prevention of cardiovascular diseases

, 2008
Ben van Steenkiste, Richard Grol, Trudy van der WeijdenCentre for Quality of Care Research, School for Public Health and Primary Care (Caphri), Maastricht University, Maastricht, The NetherlandsBackground: Cardiovascular disease prevention is guided by ...
Trudy van der Weijden, Ben van Steenkiste, Richard Grol   +2 more
core