Results 81 to 90 of about 9,087,892 (300)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Implementation of improvement strategies in palliative care: an integrative review [PDF]

, 2015
Contains fulltext : 153102.pdf (Publisher’s version ) (Open Access)BACKGROUND: The European population is ageing, and as a consequence, an increasing number of patients are in need of palliative care, including those with dementia ...
van Riet Paap, Jasper, Engels, Y., Wendy Moyle, Myrra Vernooij-Dassen, Hjermstad, Marianne Jensen, Kris Vissers, Vernooij-Dassen, M.J.F.J., Jasper van Riet Paap, Riet Paap, J.C. van, Sommerbakk, R., Vissers, K., Paap, Jasper van Riet, Moyle, Wendy, Marianne J. Hjermstad, Vernooij-Dassen, Myrra, Moyle, W., Sommerbakk, Ragni, Leppert, Wojciech, Hjermstad, M.J., Yvonne Engels, Vissers, Kris, null null, Wojciech Leppert, Engels, Yvonne, Hjermstad, Marianne J, Ragni Sommerbakk, Leppert, W.   +26 more
core   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Beyond “implementation strategies”: classifying the full range of strategies used in implementation science and practice [PDF]

, 2017
Background Strategies are central to the National Institutes of Health’s definition of implementation research as “the study of strategies to integrate evidence-based interventions into specific settings.” Multiple scholars have proposed lists of the ...
Sarah A. Birken, Christopher M. Shea, Jennifer Leeman, Birken, Sarah, Catherine Rohweder, Byron J. Powell, Rohweder, Catherine, Leeman, Jennifer, Shea, Christopher, Powell, Byron   +9 more
core   +1 more source

International School-Based HPV Vaccination Programmes: A Comparative Analysis and Recommendations for Adaptation to the French Context

Vaccines
Background/Objectives: School-based vaccination is a major strategy for improving human papillomavirus (HPV) vaccination coverage, but implementation varies across countries.
Sarah Soupey, Laure Hermet
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Economic evaluation in healthcare implementation: a systematic review

Frontiers in Health Services
BackgroundEconomic evaluations are critical for guiding resource allocation in healthcare but remain underutilized in implementation science. While implementation strategies such as training, infrastructure change and facilitation incur substantial costs,
Katarina Ulfsdotter Gunnarsson, Per Nilsen   +1 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Implementation strategies and stakeholders responsible by implementation phase.

, 2019
Implementation strategies and stakeholders responsible by implementation phase.
Marinda Roelofse (7871552), Katherine Sorsdahl (366817), Megan Malan (5506475), Sa’ad Lahri (7871555), Dan J. Stein (7439063), Bronwyn Myers (2187313), Tracey Naledi (4972930), Claire van der Westhuizen (7871549)   +7 more
core   +1 more source

Exploring the alignment between the Expert Recommendations for Implementing Change implementation strategies and Stages of Implementation Completion® stages

Frontiers in Health Services
BackgroundImplementation is an iterative, multistage process that requires selecting and applying strategies over time. The Universal Stages of Implementation Completion® (U-SIC) organizes implementation activities across sequential stages, whereas the ...
Ekaterina Burduli, Ekaterina Burduli, Allyson L. Dir, Mia Alexandra Navarro, Byron J. Powell, Byron J. Powell, Byron J. Powell, Byron J. Powell, Lisa Saldana   +8 more
doaj   +1 more source