Results 111 to 120 of about 675,379 (261)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Introducing Endoscopic Spine Surgery in Tanzania: Implementation Strategy and Early Clinical Outcomes. [PDF]

Global Spine J
Garvayo M, Sabas RR, Shabani HK, Rutabasibwa N, Gendelberg D, Cadieux M, Mzingi M, Härtl R, Park DY, Kashlan O.   +9 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Usability and feasibility of the longitudinal implementation strategy tracking system: a think-aloud study with implementation researchers. [PDF]

Front Health Serv
Merle JL, Smith JD.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Ready to screen implementation trial protocol: a cluster randomized implementation trial comparing a bundled implementation strategy versus a simple implementation strategy to improve intention to screen in the Australian National Lung Cancer Screening Program. [PDF]

Implement Sci
Kartal D, Paul C, Bartlett G, Abraham S, York S, Bonevski B, Emery JD, Vinod SK, Brims F, Barker D, Dodd RH, McCullough S, Tse J, Rhee J, Brooke M, May J, Norris S, Lantin MAR, Nicholls T, Marshall HM, Stone E, Onwuka S, Quaife SL, Rankin NM.   +23 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Implementation strategy for data-driven surgical systems: a South African perspective. [PDF]

BMJ Health Care Inform
Kluyts HL, Biccard BM, Chu K, Maswime S, Crisp N.   +4 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Using end user feedback to specify an adaptive implementation strategy. [PDF]

Front Health Serv
Massey-Swindle T, Rutledge JM, Johnson SL, Curran GM.   +3 more
europepmc   +1 more source