Results 111 to 120 of about 7,515,929 (289)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Strategy-proofness, requiring that truth-telling is a dominant strategy, is a standard concept in social choice theory. However, this concept has serious drawbacks.
Tomas Sjostrom +2 more
core
Kisumu City County Agri-Nutrition Strategy Paper 2023-2027
, 2023 The Kisumu County Agri-Nutrition Implementation Strategy (CANIS) has been developed at a time when the world, Kenya, and Kisumu are experiencing challenges to adequate, safe, and nutritious food for their populations.
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Implementation Science CommunicationsBackground Implementation research plays a key role in bridging the gap between evidence and practice, particularly in low-resource settings. In Ethiopia, persistent challenges in healthcare access, quality, and system performance highlight the need for ...
Berhanu Fikadie Endehabtu +8 more
doaj +1 more source
Strategy for Community Health 2014-2019: Transforming health: Accelerating the attainment of health goals [PDF]
, 2014 Kenya Vision 2030 emphasizes preventive health care and health promotion to improve health care and reduce the burden of illness in the community. In 2006, the Ministry of Health developed and adopted the community health strategy as a core component of ...
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Cadernos EBAPE.BRO presente artigo tem o objetivo de avaliar como os fatores organizacionais, estrutura, liderança, cultura e comunicação influenciam no processo de implantação do Planejamento Estratégico, através de um estudo de caso. O embasamento teórico que norteou a
Juliane Ines Di Francesco Kich +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source