Results 61 to 70 of about 7,515,929 (289)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Frontiers in Health ServicesBackgroundWorkplace smoking cessation programs remain underused in small and medium-sized enterprises (SMEs) due to limited resources and implementation barriers.
Miyuki Odawara +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Secure Implementation: Strategy-Proof Mechanisms Reconsidered [PDF]
Strategy-proofness, requiring that truth-telling is a dominant strategy, is a standard concept in social choice theory. However, the concept of strategy-proofness has serious drawbacks. First, announcing one's true preference may not be a unique dominant
Sjostrom, Tomas +2 more
core
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
An integrated approach to marketing strategy formulation and implementation [PDF]
The overall aim of the thesis was to address the issues involved in marketing strategy formulation, implementation and company performance by developing a framework for the marketing of insurance services in Jordan.
Akroush, Mamoun Nadim Awwad
core +4 more sources
Global Health ActionIntegrating family-centered maternal, newborn, and child health (MNCH) services along the care continuum can improve health outcomes in low- and middle-income countries (LMICs).
Christina Schuler +4 more
doaj +1 more source
Exploration and Practice of Nanjing Metro Digital Transformation
Chengshi guidao jiaotong yanjiu[Objective] Digital transformation is an inevitable trend for urban rail transit enterprises during the shift from high-speed growth to high-quality development. It is necessary to study the top-level design, path selection, and implementation strategies
Caigao SHE +4 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Involvement of Boards in Strategy Implementation [PDF]
The classical management perspective works on the assumption that CEO can design an explicit “grand strategy” for the entire enterprise. Later strategy perspectives question these normative assumptions and depict strategy as a messy, disorderly and ...
Ovidiu BORDEAN +2 more
core