Results 71 to 80 of about 329 (205)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Mauriac: The Ambivalent Author of Absence

open access: yesStudies in 20th & 21st Century Literature, 1987
This essay explores the significance of first- and third-person narrative voices. Although, as Gérard Genette points out, the choice of either voice is not in itself significant, transitions between the two voices are.
James H. Reid
doaj   +1 more source

The Implied Reader: Patterns of Communication in Kipling's Fiction for Children [PDF]

open access: yesCDELT Occasional Papers in the Development of English Education, 2019
The purpose of this paper is to examine the patterns of communicationused by Kipling in his Just So Stories: For Little Children and howchildren react with them. It analyses the strategies and techniques used byKipling to urge children to interact with the stories.
openaire   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Bakom den leende masken

open access: yesBarnboken: Tidskrift för Barnlitteraturforskning
Theme: Motherhood and Mothering. Ill. ©Stina Wirsén Behind the Pretty Mask: Vulnerable Mothering in Contemporary Picturebooks about Surrogacy and Illness Children and adults, the dual audience of picturebooks, are joined in the act of reading ...
Tuva Haglund, Malin Nauwerck
doaj   +1 more source

Fragmente sloer in ons ore: die reaktivering van ouer literere tekste in die oeuvre van T.T. Cloete

open access: yesLiterator, 1995
Fragments linger in our ears: the re-activation of older literary texts in the oeuvre of T.T. Cloete Robert Scholes defines the vocation of the lecturer of literature as a commitment “to help our students unlock textual powers”, stressing the relation of
L. Venter
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Effective Communication in the Media Sphere: Creation of Cultural Identity

open access: yesУправленческое консультирование, 2018
The article discusses the conditions of effective communication, the key social and cultural process of society. On the basis of sociological survey among youth made in the social networks, the authors show modern trends of communication. The study draws
Vladimir Nikolaevich Kiselev   +2 more
doaj  

The performativity of ‘defining’ asides in the Fourth Gospel: A speech act perspective

open access: yesHTS Teologiese Studies/Theological Studies
The article investigates the performative nature of asides that aim to define or specify something in the Fourth Gospel. Despite scholars exploring the prevalence and significance of asides in this Gospel, there has been limited attention given to ...
Risimati S. Hobyane
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

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