Results 81 to 90 of about 329 (205)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
MATEI CĂLINESCU: CONCEPTUL DE (RE)LECTURĂ
Studia Universitatis Moldaviae: Stiinte Umanistice, 2020 Textul reactualizează principalele aspecte semantice ale conceptului călinescian de (re)lectură, raportându-l la un cadru istorico-teoretic european și românesc mai larg, cel al teoriei receptării.
Diana DEMENTIEVA
doaj
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Etyka czytania i strategie narracji. Na podstawie powieści Toni Morrison [Ethics of Reading and Narrative Strategies Based on Toni Morrison’s Novel “Beloved”] [PDF]
Analiza i Egzystencja, 2013 The article undertakes the consideration of ethics of reading in the context of narrativestrategies in reference of Toni Morrison’s novelBeloved.
Anna Glab
doaj
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Procopius' Recalcitrant Reader (Wars 1.1.6–17)
HistosA programmatic passage in the preface of Procopius of Caesarea’s Wars (1.1.6–17) focuses on how the work will be received by its implied audience. Procopius’ narrator posits two contrasting figures: one, an open-minded reader disposed to reason from ...
Charles F. Pazdernik
doaj +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
The pragmatic nature of focalisation in John 4:1–42: Reading John as a performative text
Verbum et EcclesiaThis article suggests that the process of crafting a narrative reflects the author’s intentional introduction of bias to guide the reader towards taking specific actions based on their reading.
Risimati S. Hobyane
doaj +1 more source