Results 41 to 50 of about 203,922 (217)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

Differential Biological Effects of Trifolium pratense Extracts—In Vitro Studies on Breast Cancer Models

open access: yesAntioxidants
The increasing popularity of herbal supplements emphasizes the need of scientific data regarding their health benefits and possible toxicological concerns.
Lucian Albulescu   +4 more
doaj   +1 more source

CONSIDERING THE PROSPECTS OF PARALLEL IMPORT

open access: yesВестник университета, 2019
The issue of parallel import is сomplex. The problem has geopolitical nature. The price of the existing ban is billions of dollars in overpayment for imported goods per year, because of it, the structure of domestic trade in Russia is extremely ...
V. Kardanov
doaj   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

open access: yesFEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

TRUST RATIONALIZERS AS THE INSTITUTIONAL INFRASTRUCTURE OF FINANCIAL MARKETS: A CONCEPTUAL FRAMEWORK FOR STRUCTURED TRUST ELASTICITY

open access: yesФінансово-кредитна діяльність: проблеми теорії та практики
Modern financial markets operate under conditions of increasing information asymmetry, making independent risk assessment increasingly difficult and shifting the process of trust formation toward specialized intermediaries.
Руслан Гриценко
doaj   +1 more source

Analysis of foreign direct investment in the Czech Republic

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011
The foreign direct investments are joined with the process of world globalisation. Foreign direct investments are carried out especially by multinational companies.
Marcela Domesová
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

open access: yesFEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez   +4 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

open access: yesFEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Effects of lending rates and financial development on loan portfolio in sub-Saharan Africa

open access: yesFuture Business Journal
This study investigates the complex dynamics between lending interest rates, loan portfolio structures, and financial sector development in Sub-Saharan Africa (SSA).
David Aboagye Danquah, Kofi Osei Adu
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

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