Results 31 to 40 of about 197,212 (334)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Actual issues of tax policy of Russia in the conditions of import replacement
Ученые записки Российской академии предпринимательства, 2021 Materials and methods. The article examines the approaches of modern Russian scientists to the definition of the current state and prospects for the development of import substitution in Russia; the possible directions of tax incentives for innovative ...
R. B. Rubinov, A. A. Iskandaryan
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
IMPORT SUBSTITUTION IN THE RUSSIAN TOURISM INDUSTRY
Финансы: теория и практика, 2017 The intensive import substitution in the economy caused by the anti-Russian US and EU sanctions also involves the Russian tourism industry. The paper analyzes internal and external factors leading to the import substitution expansion in the Russian ...
N. M. Mukhetdinova
doaj +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Brazilian Journal of Political Economy, 2005 This work estimates the import substitution process in Brazilian industrial sectors in a recent period and evaluates whether it is occurring naturally or is in part induced by some kind of external commercial policy.
Ana Maria de Paiva Franco +1 more
doaj +1 more source
Import substitution as a means of image forming: Forecasting of prospects of industrial enterprises [PDF]
, 2014 A scheme of import substitution strategy forming on the basis of innovative development analysis is proposed in the article that is a factor of the enterprise image increasing.
Kolodka, Anna Vitaliivna +8 more
core +1 more source
Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control
Advanced Engineering Materials, EarlyView.This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian +4 more
wiley +1 more source