Results 111 to 120 of about 1,481,275 (287)
Advanced Science, EarlyView.Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li +11 more
wiley +1 more source
Setting of import tolerances for difenoconazole in various crops
EFSA JournalIn accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Syngenta Crop Protection AG submitted an application to the competent national authority in Spain (rapporteur Member State, RMS) to set import tolerances for the active substance ...
European Food Safety Authority (EFSA) +21 more
doaj +1 more source
Rules of origin and the web of East Asian free trade agreements [PDF]
The authors provide an overview of the preferential rules of origin in East Asia, highlighting the aspects that might possibly generate some trade-chilling effects.
Manchin, Miriam +1 more
core
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Post-Moratorium EU Regulation of Genetically Modified Products: Triffid Flax [PDF]
The regulatory regime for contamination permits the imposition of import bans with neither a scientific justification nor a risk assessment. No scientific assessment of Triffid flax was done prior to the import ban. The import regime put in place to deal
Kerr, William A. +2 more
core +1 more source
Advanced Science, EarlyView.This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui +9 more
wiley +1 more source
Bays in Peril: A Forecast for Freshwater Flows to Texas Estuaries [PDF]
, 2004 Takes a look at increasing water demands in Texas, and what would happen to the inflows to the seven major estuaries if existing water permits were fully used and wastewater reuse increased.
Norman D. Johns
core
Advanced Science, EarlyView.This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang +10 more
wiley +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
, 2015 We have developed a non-sequential ray-tracing simulation library, ROOT-based simulator for ray tracing (ROBAST), which is aimed to be widely used in optical simulations of cosmic-ray (CR) and gamma-ray telescopes.
Noda, Koji +2 more
core +1 more source