Results 51 to 60 of about 371,594 (213)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Land-cover classification in Addo Elephant National Park: Analyzing the impact of variables, classifiers, and object-based approach

Ecological Informatics
A comprehensive understanding of land-use and land-cover (LULC) dynamics is vital in steering effective conservation and management efforts, especially in ecologically rich regions like Addo Elephant National Park (AENP).
Mohammad Safaei, Jane Southworth, Cerian Gibbes, Hannah V. Herrero, Mashoukur Rahaman, Bewuket B. Tefera, Jason K. Blackburn   +6 more
doaj   +1 more source

Large Scale Mowing Event Detection on Dense Time Series Data Using Deep Learning Methods and Knowledge Distillation [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
The intensity of agricultural land use is a critical factor for food security and biodiversity preservation, necessitating effective and scalable monitoring techniques. This study presents a novel approach for large-scale mowing event frequency detection
T. Moumouris, V. Tsironis, A. Psalta, K. Karantzalos   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Deep Learning Unravels Differences Between Kinematic and Kinetic Gait Cycle Time Series from Two Control Samples of Healthy Children Assessed in Two Different Gait Laboratories

Sensors
We investigate the application of deep learning in comparing gait cycle time series from two groups of healthy children, each assessed in different gait laboratories. Both laboratories used similar gait analysis protocols with minimal differences in data
Alfonso de Gorostegui, Damien Kiernan, Juan-Andrés Martín-Gonzalo, Javier López-López, Irene Pulido-Valdeolivas, Estrella Rausell, Massimiliano Zanin, David Gómez-Andrés   +7 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Evaluation and Selection of Multi-Spectral Indices to Classify Vegetation Using Multivariate Functional Principal Component Analysis

Remote Sensing
The identification, classification and mapping of different plant communities and habitats is of fundamental importance for defining biodiversity monitoring and conservation strategies.
Simone Pesaresi, Adriano Mancini, Giacomo Quattrini, Simona Casavecchia   +3 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source