Results 241 to 250 of about 2,707,715 (327)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Accelerated Evaluation of Automated Vehicles Safety in Lane-Change Scenarios Based on Importance Sampling Techniques. [PDF]

IEEE trans Intell Transp Syst, 2017
Zhao D, Lam H, Peng H, Bao S, LeBlanc DJ, Nobukawa K, Pan CS.   +6 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A new method for estimating the demographic history from DNA sequences: an importance sampling approach. [PDF]

Front Genet, 2015
Ait Kaci Azzou S, Larribe F, Froda S.
europepmc   +1 more source

Adaptive Importance Sampling Monte Carlo Simulation of Rare Transition Events

, 2004
M de Koning, W Cai, B Sadigh, T Oppelstrup, M H Kalos, V V Bulatov   +5 more
openalex   +1 more source

Importance Sampling of Rare Events for Distribution Networks with Stochastic Loads

M. H. M. Christianen, Henry Lam, Maria Vlasiou, Bert Zwart   +3 more
openalex   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The jigsaw puzzle of sequence phenotype inference: Piecing together Shannon entropy, importance sampling, and Empirical Bayes. [PDF]

J Theor Biol, 2015
Shreif Z, Striegel DA, Periwal V.
europepmc   +1 more source

Rethinking Importance Sampling in LLM Policy Optimization: A Cumulative Token Perspective

Yuheng Zhang, Chenlu Ye, Shuowei Jin, Changlong Yu, Wei Xiong, Saurabh Sahu, Nan Jiang   +6 more
openalex   +1 more source

Expanded molecular phylogeny of the genus Bicyclus (Lepidoptera: Nymphalidae) shows the importance of increased sampling for detecting semi-cryptic species and highlights potentials for future studies

, 2016
Kwaku Aduse‐Poku, Paul M. Brakefield, Niklas Wahlberg, Oskar Brattström   +3 more
openalex   +1 more source