Results 251 to 260 of about 2,707,715 (327)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Adaptive importance sampling for network growth models. [PDF]

Ann Oper Res, 2011
Guetz AN, Holmes SP.
europepmc   +1 more source

The importance of different frailty domains in a population based sample in England

SA Arnadottir (21914498), J Bruce (15981689), R Lall (13399542), EJ Withers (15832244), M Underwood (11812397), F Shaw (13492261), R Sheridan (9626483), A Hossain (14595350), SE Lamb (7808927), F Martin (11142185), L Yardley (7705367), D Skelton (13657426), K Willett (13369215), S Eldridge (7726538), AM Slowther (21899945), S Duggan (13279770), S Hennings (21914501), E Withers (17272438), R Mant (21914504), R Rai (14066772), C Turner (6005675), A Andrews (10651535), R Fearn (21914507), S Finnegan (21914510), N Walker (7801505), R Potter (12145530), C Hulme (9896243), C Bojke (21914513), R Longo (16198718), K Westacott (21914516), S Ralhan (21282509), J Treml (21914519), J Riglin (21914522), H Gordjin (21914525), R Dutta (15651290), J Burns (10165235), J Davison (8412213), A Willis (7743851), C Muthiah (21914528), H Adjei (21914531)   +39 more
openalex  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A simulation is worth a thousand worlds - Importance sampling Monte Carlo applied to COVID-19 contingency

, 2020
Rapuzzi A, Vairo T.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Importance sampling of word patterns in DNA and protein sequences. [PDF]

J Comput Biol, 2010
Chan HP, Zhang NR, Chen LH.
europepmc   +1 more source

Mollusc species richness and abundance from shelf to abyssal depths in the Ross Sea (Antarctica): the importance of fine-mesh-towed gears and implications for future sampling

, 2017
Claudio Ghiglione, Maria Chiara Alvaro, Paola Piazza, David A. Bowden, Huw J. Griffiths, Cinzia Carota, Consuelo Rubina Nava, Stefano Schiaparelli   +7 more
openalex   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source