Results 51 to 60 of about 212,820 (287)

Gray Market Goods: A Lighter Shade of Black Symposium: The Controversy over the Importation of Gray Market Goods: Is a Resolution Forthcoming [PDF]

, 1987
If a street vendor offers a famous brand-name product for a substantially lower price than one would expect, the average consumer\u27s initial reaction might be that the product had been stolen or was hot - a product of the black market.
Hansen, Hugh C.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

U.S. Infringement Liability for Foreign Sellers of Infringing Products [PDF]

, 2003
With the ever-increasing international flavor of business comes an important question for United States patent holders and foreign manufacturers alike: Can a company be held liable for patent infringement in the United States for selling an infringing ...
Petersen, Troy
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Incidence of dengue virus infection among Japanese travellers, 2006 to 2010

Western Pacific Surveillance and Response, 2012
Introduction: Dengue continues to be a global public health concern. In Japan, although dengue cases are currently seen only among travellers returning from endemic areas, the number of reported cases is rising according to the national case-based ...
Yuki Tada, Tamano Matsui, Tomoe Shimada, Naomi Nakamura, Yuzo Arima, Nobuhiko Okabe   +5 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Clinical Features That Increase Suspicion of Brucella canis Infection in Dogs With Discospondylitis: A Multicenter Case–Control Study

Journal of Veterinary Internal Medicine
Background Brucella canis is an important cause of discospondylitis in dogs, and brucellosis can be challenging to diagnose. Early recognition could aid in early implementation of precautions to limit zoonotic transmission.
Courtney M. Moeller, Joseph W. Bartges, Kelsey D. Brust, Philip H. Kass, Rebecca F. Kelly, Erin W. Lashnits, Chai‐Fei Li, Lindsay K. Merkel, Jessica C. Pritchard, Jane E. Sykes   +9 more
doaj   +1 more source

Epidemiologic Situation on Cholera in the World, CIS Countries and Russia. Prognosis

Проблемы особо опасных инфекций, 2010
Epidemiologic situation on cholera in the world, CIS countries and Russia has been evaluated for the period of 2000-2009. The last decade (2000-2009) is characterized by the on-going large epidemics and outbreaks of cholera in the countries of Africa and
Yu. M. Lomov, E. A. Moskvitina
doaj   +1 more source