Results 51 to 60 of about 212,518 (290)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
RiskEstim: A Software Package to Quantify COVID-19 Importation Risk
Frontiers in Physics, 2022 We present an R package developed to quantify coronavirus disease 2019 (COVID-19) importation risk. Quantifying and visualizing the importation risk of COVID-19 from inbound travelers is urgent and imperative to trigger public health responses ...
Mingda Xu +15 more
doaj +1 more source
Negotiating identities: ethnicity and social relations in a young offenders' institution [PDF]
, 2008 This article explores the situated nature of male prisoner identities in the late modern British context, using the contrasting theoretical frames of Sykes's (1958) indigenous model and Jacobs' (1979) importation model of prisoner subcultures and social ...
Allport, Gordon W. +29 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Проблемы особо опасных инфекций, 2023 The risk of importation of infectious diseases is an urgent threat to sanitary and epidemiological well-being of the population, both at the level of individual countries and interstate associations, and globally.
A. A. Zubova +5 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Gray Market Goods: A Lighter Shade of Black Symposium: The Controversy over the Importation of Gray Market Goods: Is a Resolution Forthcoming [PDF]
, 1987 If a street vendor offers a famous brand-name product for a substantially lower price than one would expect, the average consumer\u27s initial reaction might be that the product had been stolen or was hot - a product of the black market.
Hansen, Hugh C.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The role of TPLs in innovative logistics solutions in importation [PDF]
Innovation & Management Review, 2018 Purpose - The purpose of this paper is to investigate the role of third-party logistics providers (TPLs) in providing innovative logistics solutions for Brazilian importations.
Alessandra Vitorino Razzera +1 more
doaj +1 more source
Chocolate Manufacturers Join Bush administration in Effort to Prevent Enforcement of US Laws Banning Importation of Good Made With Child/Slave Labor [PDF]
, 2005 This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
International Labor Rights Forum
core +1 more source