Results 51 to 60 of about 59,978 (299)

Permutation importance: a corrected feature importance measure [PDF]

open access: yesBioinformatics, 2010
Abstract Motivation: In life sciences, interpretability of machine learning models is as important as their prediction accuracy. Linear models are probably the most frequently used methods for assessing feature relevance, despite their relative inflexibility.
André Altmann   +3 more
openaire   +3 more sources

Patents and Drug Importation [PDF]

open access: yes, 2004
This report explores the intellectual property laws and policies concerning the parallel importation of patented pharmaceuticals into the United ...
Thomas, John R.
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Cholera: Assessment of Epidemiological Situation on Cholera around the World and in Russia in 2008–2017. Forecast for 2018

open access: yesПроблемы особо опасных инфекций, 2018
The trend of morbidity reduction at an average annual rate of 1.113 % in 2017 (in comparison to 2008) continues. The tendency of intensive monthly cholera incidence growth around the world in 2017 in relation to 2015 and 2016 is established. 25 countries
E. A. Moskvitina   +10 more
doaj   +1 more source

La presse et ses passeurs méconnus, intermédiaires indispensables à la circulation de la littérature américaine en France dans les années 1940

open access: yesTransatlantica, 2023
The French press was a crucial intermediary for the circulation of US literature in France during the 1940s. However, its role in this importing process has rarely been studied.
Anne Cadin
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Assessment of Cholera Epidemiological Situation in the World in the Present Period. Prognosis

open access: yesПроблемы особо опасных инфекций, 2011
In the first decade of the XXI century large-scale cholera epidemics and outbreaks were registered in African, Asian, and North American countries.
Yu. M. Lomov   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

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