Results 51 to 60 of about 31,862 (267)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Estimating probabilities of malaria importation in southern Mozambique through modelling P. falciparum genomics and mobility patterns

eLife
Imported malaria is a critical obstacle to achieving elimination in low transmission settings, but importation classification tools combining human mobility and parasite genomics are lacking.
Arnau Pujol, Arlindo Chidimatembue, Clemente da Silva, Simone Boene, Henriques Mbeve, Pau Cisteró, Carla García-Fernández, Arnau Vañó-Boira, Dário Tembisse, José Inácio, Glória Matambisso, Fabião Luis, Nelo Ndimande, Humberto Munguambe, Lidia Nhamussua, Wilson Simone, Andrés Aranda-Díaz, Manuel García-Ulloa, Neide Canana, Maria Tusell, Júlia Montaña, Laura Fuente-Soro, Khalid Ussene Bapu, Maxwell Murphy, Bernardete Rafael, Eduard Rovira-Vallbona, Caterina Guinovart, Bryan Greenhouse, Sonia Maria Enosse, Francisco Saúte, Pedro Aide, Baltazar Candrinho, Alfredo Mayor   +32 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Epidemiologic Situation on Cholera in the World, CIS Countries and Russia. Prognosis

Проблемы особо опасных инфекций, 2010
Epidemiologic situation on cholera in the world, CIS countries and Russia has been evaluated for the period of 2000-2009. The last decade (2000-2009) is characterized by the on-going large epidemics and outbreaks of cholera in the countries of Africa and
Yu. M. Lomov, E. A. Moskvitina
doaj   +1 more source

The role of TPLs in innovative logistics solutions in importation [PDF]

Innovation & Management Review, 2018
Purpose - The purpose of this paper is to investigate the role of third-party logistics providers (TPLs) in providing innovative logistics solutions for Brazilian importations.
Alessandra Vitorino Razzera, Marcelo André Machado   +1 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Clinical Features That Increase Suspicion of Brucella canis Infection in Dogs With Discospondylitis: A Multicenter Case–Control Study

Journal of Veterinary Internal Medicine
Background Brucella canis is an important cause of discospondylitis in dogs, and brucellosis can be challenging to diagnose. Early recognition could aid in early implementation of precautions to limit zoonotic transmission.
Courtney M. Moeller, Joseph W. Bartges, Kelsey D. Brust, Philip H. Kass, Rebecca F. Kelly, Erin W. Lashnits, Chai‐Fei Li, Lindsay K. Merkel, Jessica C. Pritchard, Jane E. Sykes   +9 more
doaj   +1 more source

Cholera: Monitoring of Epidemiological Situation around the World and in Russia (2010–2019). Forecast for 2020

Проблемы особо опасных инфекций, 2020
Objective of the study was to monitor the spread of cholera in the world, in the CIS countries and in Russia with an assessment of risks and emergencies that contribute to the activation of the epidemic process.
E. A. Moskvitina, E. G. Yanovich, M. I. Kurilenko, V. D. Kruglikov, S. V. Titova, D. A. Levchenko, A. S. Vodop’yanov, A. A. Lopatin, S. M. Ivanova, B. M. Mishan’kin, A. S. Krivenko, G. B. Anisimova, A. K. Noskov   +12 more
doaj   +1 more source