Results 61 to 70 of about 13,922 (281)

A (re)negotiation of identity: from 'mature student' to 'novice academic' [PDF]

, 2012
The purpose of this paper is to present the findings of an investigation into the first-year experience of mature students. The research focuses on the identity shift that these students underwent throughout the year and problematises the construct of ...
Chapman, Amanda
core   +2 more sources

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

An unusual delusion of duplication in a patient affected by Dementia with Lewy bodies [PDF]

, 2017
Background: Dementia with Lewy bodies (DLB) is the second most frequent diagnosis of progressive degenerative dementia in older people. Delusions are common features in DLB and, among them, Capgras syndrome represents the most frequent disturbance ...
SOLLA, PAOLO, MURA, GIOIA, FLORIS, GIANLUCA, FONTI, DAVIDE, OROFINO, GIANNI, CARTA, MAURO, MARROSU, FRANCESCO, Cannas, Antonino   +7 more
core   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Studying Cat (Felis catus) Diabetes: Beware of the Acromegalic Imposter [PDF]

, 2015
Naturally occurring diabetes mellitus (DM) is common in domestic cats (Felis catus). It has been proposed as a model for human Type 2 DM given many shared features.
AC Dirtu, AF Daly, AL Prahl, Andrew Wolfe, CC Capen, CE Reusch, Christopher R. Lamb, CR Lamb, David B. Church, E Resmini, ED Aflorei, H Biering, JD Nabarro, JWM Höppener, Ken Smith, KH Johnson, M Hoenig, M Hoenig, M Scacchi, MJ Brearley, MO Thorner, MS Lewitt, Márta Korbonits, N Alt, N Kokka, Norelene Harrington, O Alexopoulou, Panagiotis Mantis, PI Shishko, PJ Kenny, PW Rosario, R Gostelow, R Lederer, R Tyson, Rob Fowkes, S Melmed, SJ Niessen, SJ Niessen, SJ Niessen, SJ Niessen, Stijn J. M. Niessen, TD O'Brien, TM McCann, Y Forcada, Yaiza Forcada   +44 more
core   +3 more sources

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Computational thinking and academic imposter syndrome: a serial mediation model of creative and critical thinking

Frontiers in Psychology
ObjectiveThis study aimed to examine the relationships among computational thinking, creative thinking, critical thinking, and academic imposter syndrome within a serial mediation framework.
Adem Yilmaz, Mehmet Koray Serin
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Caregiver and Clinician Assessment of Behavioral Disturbances: The California Dementia Behavior Questionnaire [PDF]

, 1997
As part of a multicenter project to study noncognitive behavioral disturbances in dementia, the authors developed a comprehensive caregiver-rated questionnaire for these behaviors.
Mungas, Dan, Nielson, Kristy A., Victoroff, Jeff   +2 more
core   +1 more source