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Results 121 to 130 of about 21,145 (299)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source

People from impoverishment to empowerment

, 1995
People: From Impoverishment to Empowerment examines the large, unfinished agenda of human deprivation at the turn of the century. Social problems are rampant in almost every country.
Kırdar, Üner
core

Homeless not Hopeless: A Protest against Global Oppression and Impoverishment [PDF]

, 2015
The thematic concern of this paper is to zero in on the problems being faced by the homeless citizens of the world: the down-trodden, the hoi polloi who are perpetually at the receiving ends of the avaricious machinations of the political class. The blue-
Aruleba ;, Oke Fabamise Aruleba, Oke Fabamise +2 more
core

Key indicators of the concept of impoverishment due to health spending.

, 2014
Key indicators of the concept of impoverishment due to health spending.
Priyanka Saksena (632510) +2 more
core +1 more source

Incidence and intensity of catastrophic health expenditure and impoverishment among the elderly: an empirical evidence from India

Scientific Reports
World health statistics (2022) report that about 1.4 billion people have incurred catastrophic health expenditure (CHE), and half of its population have pushed into extreme poverty due to healthcare payments. The elderly population faces a higher risk of
Fahimuddin Ahmad, Pratap Chandra Mohanty
doaj +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source

Global impoverishment of natural vegetation revealed by dark diversity.

Global impoverishment of natural vegetation revealed by dark ...
Koenraad Van Meerbeek (4605265) +229 more
core

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source

Determinants of catastrophic health expenditure and impoverishment for injury-related hospitalization.

, 2019
Determinants of catastrophic health expenditure and impoverishment for injury-related hospitalization.
Deepshikha Sharma (607547) +6 more
core +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source

poverty
humans
catastrophic health expenditure

medicine
public aspects of medicine
1. no poverty

china
medical impoverishment
resettlement