Results 141 to 150 of about 21,145 (299)

AmpliPhy improves gene trees by adding homologous sequences without affecting alignments. [PDF]

Bioinform Adv
Kim D, Gil M, Katoh K, Dessimoz C.
europepmc   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Catastrophic health care, poverty and impoverishment in the Philippines

, 2008
The paper attempts to describe catastrophic health spending and its impact on poverty in the Philippine setting. It focuses on the role of out-of-pocket payments for health care as a springboard for measuring the magnitude and analysing the extent of ...
Ico, Ronaldo D.
core  

Catastrophic health expenditures and medical impoverishment in Bangladesh: evidence from the Household Income and Expenditure Survey. [PDF]

BMJ Open
Sarker AR, Islam R, Tran-Duy A.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Financial protection failure among urban poor populations in Karachi, Pakistan: a cross-sectional household survey of catastrophic health expenditure prevalence, determinants and insurance effectiveness. [PDF]

BMJ Public Health
Khan A, Khan SA, Akbari-Sari A, Hosseini M, Takian A.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Maternity or catastrophe: a study of household expenditure on maternal health care in India [PDF]

, 2013
Chandra, R., Mukherjee, S., Singh, Aditya   +2 more
core   +1 more source

Embodied Sensory Deprivation Hypothesis (ESDH): An Evolutionary Model of Sensory Malnutrition Linking Interoceptive Dysregulation, Anxiety, and Disorders of Gut-Brain Interaction. [PDF]

Cureus
Bertuccioli A, Palazzi CM, Zonzini GB, Belli A, Di Pierro F, Cardinali M.   +5 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source