Results 51 to 60 of about 130,957 (290)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

PLA/WOOD BIOCOMPOSITES: IMPROVING COMPOSITE STRENGTH BY CHEMICAL TREATMENT OF THE FIBERS [PDF]

open access: yes, 2013
A resol type phenolic resin was prepared for the impregnation of wood particles used for the reinforcement of PLA. A preliminary study showed that the resin penetrates wood with rates depending on the concentration of the solution and on temperature ...
Acha   +44 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Characterization of pacific silver fir impregnated with extractives from western redcedar

open access: yesMaderas: Ciencia y Tecnología, 2019
Alternative and higher value uses are needed for residual materials generated from wood products processing. Western redcedar sawdust contains an array of unique chemicals and has the potential to be used to alter the appearance, stability and ...
Rod Stirling, Stacey Kus
doaj  

Study of the Impregnation of Power-Transformer Cellulosic Materials With Dielectric Ester Oils

open access: yesIEEE Access, 2021
The application of alternative dielectric oils as esters in power transformers is hindered by the lack of knowledge regarding their properties and respecting which are the best techniques to ensure their proper performance.
Jaime Sanz   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Effects of veneer drying at high temperature and chemical treatments on equilibrium moisture content of plywood

open access: yesMaderas: Ciencia y Tecnología, 2014
Moisture content (MC) is one of the most important factors that can affect many physical and mechanical properties of wood and veneers. MC strongly affects the final strength and durability of joints, development of surface checks in the wood and ...
Ismail Aydin
doaj  

Supercapacitor Cell Performance with Bacterial Nanocellulose and Bacterial Nanocellulose/Polybenzimidazole Impregnated Membranes as Separator

open access: yesMembranes
Supercapacitors are advanced energy storage devices renowned for their rapid energy delivery and long operational lifespan, making them indispensable across various industries.
Hristo Penchev   +7 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

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