Results 71 to 80 of about 81,149 (258)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Nano sized Fe–Al oxide mixed with natural maize cob sorbent for lead remediation
Materials Research Express, 2019 The present work involves the synthesis, characterization and sorption behavior of Fe–Al–MC nanocomposite for the removal of Pb (II) ions from industrial waste water. The sorbent was synthesized by impregnation method.
Hizkeal Tsade +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Study of the Effects of Tannin Impregnation to Spruce Wood [PDF]
openThis thesis explores the influence of tannin concentration and cross-linking agents on the impregnation, leaching resistance, mechanical performance, and color stability of Norway spruce (Picea abies).
JOHNSON, CHRISTINA MARIE
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
BioResources, 2023 A silane-siloxane based water-repellent substance (S-WR) was used as an impregnation material for Scots pine (Pinus sylvestris L.), black pine (Pinus nigra Arnold), sessile oak (Quercus petraea Liebl.), and cedar (Cedrus libani A. Rich).
Abdi Atilgan
doaj
Adsorptive removal of Pb(II) from industrial effluent using nitric acid modified activated carbon: Optimization using Taguchi method [PDF]
Journal of the Serbian Chemical SocietyThe study aimed to examine the use of nitric-acid-modified granular activated carbon to treat the wastewater of a lead-acid battery recycling unit for lead removal. The adsorbent was characterized using FTIR, SEM and XRD analyses.
Meshram Saurabh +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source