Results 121 to 130 of about 1,760,093 (366)

Urban Dynamics an Impression of Surabaya's Sociolinguistic Setting [PDF]

open access: yes, 2009
This paper examines the sociolinguistic situation in the city of Surabaya, bypresenting an impression of various phenomena unique to Indonesia's secondlargest city.
Hoogervorst, T. G. (Tom)
core  

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Computer-aided design of bevel gear tooth surfaces [PDF]

open access: yes
This paper presents a computer-aided design procedure for generating bevel gears. The development is based on examining a perfectly plastic, cone-shaped gear blank rolling over a cutting tooth on a plane crown rack.
Coy, John J.   +2 more
core   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

CLINICAL EVALUATION OF THE ERRORS OF FIXED PROSTHODONTIC IMPRESSIONS

open access: yesRomanian Journal of Oral Rehabilitation
The precise transfer of the elements of the prosthetic field requires a good knowledge of soft and hard tissue anatomy, especially in the area of the cervical finish line.
Steliana-Gabriela Buștiuc   +6 more
doaj   +1 more source

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