Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Comparative In Vitro Assessment of the Antimicrobial Properties of Irreversible Hydrocolloid Impression Material Modified with Two Different Nanoparticles. [PDF]
CureusG HB +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Evaluation of Polytetrafluoroethylene (PTFE) Tape for Gingival Displacement Using CAD/CAM Analysis and Scanning Electron Microscopy (SEM). [PDF]
J Funct BiomaterRusu LM +7 more
europepmc +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Bridging semantics and clinical fidelity: a section-based assessment of a vision-language model (RadVLM) for chest x-ray report generation. [PDF]
Front Digit HealthAlzughaibi S.
europepmc +1 more source
Impression-CLIP: Contrastive Shape-Impression Embedding for Fonts [PDF]
Fonts convey different impressions to readers. These impressions often come from the font shapes. However, the correlation between fonts and their impression is weak and unstable because impressions are subjective. To capture such weak and unstable cross-
Uchida, Seiichi +2 more
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Evaluating large language models for lay summaries of radiology reports using tailored prompting strategies and mixed-method assessment. [PDF]
PLOS Digit HealthTasneem N +6 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source