Results 151 to 160 of about 393,960 (308)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2019 The aim of this contribution is to expand the notion of ecosystems deterioration beyond its necessary but limited materialist sense to include the flattening of their perceptive qualities. Defining the ecosystem as a set of complex relationships between the living subjects and the environment, this essay argues that such relationships include ...
openaire +2 more sources
Understanding the Dynamics of Impression Management on Social Network Sites
, 2013 This study endeavors to examine the dynamics of impression management (IM) on social network sites (SNSs). In order to attract and retain users, a SNS would need to manage the services for active users to build impressions that one intends to deliver and
Wu, Ya-ling; Shang, Shari S.-C.
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Contrast bias, not confirmation bias, shapes daily impression updating across social and non-social targets. [PDF]
Br J Soc PsycholLi Y +4 more
europepmc +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Occlusal Adjustment in Free-End Implant-Supported Restorations: Digital Scans Versus Conventional Impressions With Full- and Half-Arch Techniques. [PDF]
Clin Exp Dent ResNakhaei M +6 more
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source