Results 241 to 250 of about 314,979 (300)

Self-Presentation Concerns Among Injured Adolescent Athletes: A Qualitative Investigation. [PDF]

open access: yesInt J Environ Res Public Health
Demers N   +5 more
europepmc   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs   +4 more
wiley   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

open access: yesAdvanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng   +12 more
wiley   +1 more source

Home-Based Biofeedback for Fecal Incontinence: A Randomized Clinical Trial. [PDF]

open access: yesUrogynecology (Phila)
Patel UJ   +4 more
europepmc   +1 more source

SMART: preliminary efficacy, feasibility and acceptability of a theory-informed digital intervention for metabolic health in people with schizophrenia and related disorders. [PDF]

open access: yesBJPsych Open
Arnautovska U   +12 more
europepmc   +1 more source

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