Results 131 to 140 of about 2,458,834 (308)

Total Synthesis of Talarolide A and atrop-Talarolide A: Hydroxamate H-Bond Bridge Stabilization of Cyclic Peptide Conformers Invokes Non-Canonical Atropisomerism

Marine Drugs
The first total synthesis of the Australian marine tunicate fungus-derived cyclic peptide talarolide A (1) has confirmed the structure previously proposed on the basis of spectroscopic and chemical analyses and re-affirmed the importance of the unique ...
Waleed M. Hussein, Yuxuan Zhu, Angela A. Salim, Robert J. Capon   +3 more
doaj   +1 more source

ADC Mapping With 12 b Values: Can We Improve Image Quality In The Diffusion Sequence of Prostate MRI?

Journal of Radiology and Clinical Imaging, 2023
Lucas Scatigno Saad, George De Queiroz Rosas, Homero José De Farias E Melo, Jacob Szejnfeld.   +3 more
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Extreme Value at Risk and Expected Shortfall during Financial Crisis [PDF]

This paper investigates Value at Risk and Expected Shortfall for CAC 40, S&P 500, Wheat and Crude Oil indexes during the 2008 financial crisis. We show an underestimation of the risk of loss for the unconditional VaR models as compared with the ...
D. Dupre, O. Taramasco, L. Kourouma, G. Sanfilippo   +3 more
core  

Circulating Tumor Cells Enhance Prognostic Stratification Beyond ER Assessment by Biopsy or FES-PET in Endocrine-Treated Metastatic Breast Cancer

Diagnostics
Background/Objectives: Outcome prediction in patients with estrogen (ER)-positive metastatic breast cancer (MBC) remains challenging. We investigated whether circulating tumor cell (CTC) count adds prognostic value in ER-positive MBC using ...
Bertha Eisses, Lindsay Angus, Evelien J. M. Kuip, C. Willemien Menke-van der Houven van Oordt, Bert van der Vegt, Andor W. J. M. Glaudemans, Adrienne H. Brouwers, Daniela E. Oprea-Lager, Wim J. G. Oyen, Jasper Emmering, Anieta M. Sieuwerts, Agnes Jager, Jaco Kraan, John W. M. Martens, Elisabeth G. E. de Vries, Stefan Sleijfer, Carolina P. Schröder   +16 more
doaj   +1 more source

A Novel Method for Improving the Robustness of Rock Acoustic Emission b Value Estimation through Data Volume Expansion

Lithosphere
Abstract The slope b in Gutenberg–Richter (G–R) relationship is an essential parameter to describe the size distribution characteristics from small-scale acoustic emission (AE) to large-scale natural earthquake. Stable and accurate b value estimation is vital when analyzing rock damage and seismic hazards through the spatial and temporal
Daolong Chen, Xiling Liu
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Modeling churn using customer lifetime value. [PDF]

The definition and modeling of customer loyalty have been central issues in customer relationship management since many years. Recent papers propose solutions to detect customers that are becoming less loyal, also called churners.
Croux, Christophe, Baesens, Bart, Glady, Nicolas   +2 more
core  

Implementation of Cinematic Rendering in Otolaryngology Education

International Medical Education
Background: The complex anatomy of the head and neck region challenges medical students. Cinematic rendering (CR) is an advanced visualization technique that enables three-dimensional (3D) representation of cross-sectional image data and is used in ...
Thomas Ziegler, Nikolaus Poier-Fabian, Jan Maximilian Janssen, Michael Mayrhofer, Paul Martin Zwittag   +4 more
doaj   +1 more source