Results 111 to 120 of about 117,773 (298)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Competitive Elimination Improved Differential Evolution for Wind Farm Layout Optimization Problems
MathematicsThe wind farm layout optimization problem (WFLOP) aims to maximize wind energy utilization efficiency under different wind conditions by optimizing the spatial layout of wind turbines to fully mitigate energy losses caused by wake effects.
Sichen Tao +4 more
doaj +1 more source
A Search Method of NN Reducer’s Transmission Ratio
Jixie chuandong, 2022 The transmission ratio of NN reducer is discrete and nonlinear, and the gear matching method determines the volume and stability of a reducer. In previous studies， most scholars tried to find out the key parameters affecting the change of transmission ...
Yifei Lin +5 more
doaj
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Hybrid differential evolution - Scatter search algorithm for permutative optimization [PDF]
, 2016 This chapter deals with modified version of DE algorithm, enriched by scatter search to show its improved performance.
Zelinka, Ivan +2 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Improved differential evolution implemented in parallel processing
, 2014 The aim of this work is to present an improvement of the heuristic optimization method of Differential Evolution proposing modifications to its basic algorithm by using the concept of evolution with Shuffled Sets.
Brandão, Milena Almeida Leite
core +1 more source
Optimal Reactive Power Dispatch using Improved Differential Evolution Algorithm
Majlesi Journal of Electrical EngineeringReactive power dispatch plays a key role in secure and economic operation of power systems. Optimal reactive power dispatch (ORPD) is a non-linear optimization problem which includes both continues and discrete variables.
Hamid Falaghi, Arsalan Najafi
doaj