Results 101 to 110 of about 1,252,934 (262)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Applying Improved Efficiency Transformers
, 1998 Today's business and energy conscious environment affords both producers and consumers of electric energy an opportunity to reduce costs and conserve energy through the use of improved efficiency transformers. Various design techniques that manufacturers
Haggerty, N. K., Malone, T. P.
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Energy efficiency and the rebound effect
, 2009 In recent years the argument that rebound effects, triggered by economy-wide price and income effects, may partially or wholly offset reductions in energy consumption expected from energy efficiency improvements has gained a great deal of attention in ...
Turner, Karen
core
Energy efficiency through industrial excess heat recovery-policy impacts
, 2015 The EU target on energy efficiency implies a 20 % reduction in the use of primary energy by implementation of energy efficiency measures. Not all potential cost-effective measures for improved energy efficiency are implemented. This energy efficiency gap
Broberg, Sarah, Broberg, Sarah,
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
OPERATING COST EFFICIENCY ON PENNSYLVANIA DAIRY FARMS
Operating cost efficiency is evaluated on Pennsylvania dairy farms using a modification of the Farrell efficient unit isoquant frontier method. Evaluating farms by herd size groups, the average measure of cost efficiency ranged from 70 to 80 percent ...
Grisley, William, Mascarenhas, Juan
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Fuel Efficiency and Motor Vehicle Travel: The Declining Rebound Effect [PDF]
We estimate the rebound effect for motor vehicles, by which improved fuel efficiency causes additional travel, using a pooled cross section of US states for 1966-2001.
Kurt Van Dender, Kenneth A. Small
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source