Results 61 to 70 of about 64,836 (265)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Research on the dynamic characteristics of the cavitation bubble collapsing between multiple particles

open access: yesUltrasonics Sonochemistry
The combined action of multiple particles and cavitation bubbles can severely damage hydraulic machinery. Combining the Kelvin impulse theory and the results of high-speed photography experiments, this paper researches the dynamic behaviors of a single ...
Xiaoyu Wang   +4 more
doaj   +1 more source

Study on Spatial-Temporal Distribution Characteristics of the Discharge Process in a 1 m Rod-Plate Gap Under Different Polarity Lightning Impulses

open access: yesIEEE Access, 2019
The observation of the air gap discharge process is the basis of revealing the physical mechanism of gas discharge and establishing the accurate numerical simulation model.
Yaqi Zhang   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Effects of Electrical Stimulation with Different Impulses on Physical Characteristics of Rabbit Meat

open access: yesAnimal Production: Indonesian Journal of Animal Production, 2010
Meat becoming less tender with age. One of the methods to increase the meat tenderness is by electrical simulation. The objective of this study was to investigate the effect of electrical simulation with different level of impulses on physical ...
H Yurmiati, GA Wiedy, S Kusmajadi
doaj  

Seasonal Influences on the Impulse Characteristics of Grounding Systems for Tropical Countries

open access: yesEnergies, 2019
One of the most important parameters of the performance of grounding systems is the soil resistivity. As generally known, the soil resistivity changes seasonally, hence the performance of grounding systems, at DC and under high impulse conditions.
Muhd Shahirad Reffin   +6 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Characteristics analysis of muzzle impulse noise based on wavelet energy spectrum

open access: yesJournal of Measurement Science and Instrumentation, 2015
Because muzzle impulse noise could cause damage to or have an influence on the operator,the effective protective measures should be taken.Therefore,correct analysis of impulse noise characteristics is very significant.Considering the shortcomings of fast
LAI Fu-wen   +3 more
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Research on Characteristics of Directional Impulse Sound Sources in a U-shape Connected Well [PDF]

open access: yesE3S Web of Conferences
The traditional U-shaped connected well connection technology mainly relies on the magnetic steering technology to guide the connection of the two wells, but the magnetic steering technology has the disadvantage of short detection distance.
Zhang Jing, Zhang Peng
doaj   +1 more source

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