Results 61 to 70 of about 74,722 (304)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Influence of Pulse Interval on Soil Dispersion Characteristics under Continuous Impulse
Advances in Electrical and Computer EngineeringUnder continuous lightning strikes, the impulse dispersion characteristics of grounding devices more effectively indicate the effectiveness of tower grounding for lightning protection.
CAO, W. +4 more
doaj +1 more source
Ultrasonics SonochemistryThe combined action of multiple particles and cavitation bubbles can severely damage hydraulic machinery. Combining the Kelvin impulse theory and the results of high-speed photography experiments, this paper researches the dynamic behaviors of a single ...
Xiaoyu Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
IEEE Access, 2019 The observation of the air gap discharge process is the basis of revealing the physical mechanism of gas discharge and establishing the accurate numerical simulation model.
Yaqi Zhang +7 more
doaj +1 more source
Characteristics of Impulse Discharges in Wet Soil
The Transactions of The Korean Institute of Electrical Engineers, 2017 This paper presents the experimental results related to soil ionization and electrical breakdown in a concentric hemispherical electrode system under lightning impulse voltages. Dynamic voltage-current and impedance-time characteristics of soil ionization were measured and analyzed. Also the electrical breakdowns of the soil gap were investigated.
Hoe-Gu Kim, Bok-Hee Lee
openaire +2 more sources
Analytical Expression for Sound Transmission Loss Calculation: An Improvement to the Existing Method after Singh and Katra [PDF]
, 2009 An analytical expression for measuring of sound transmission loss (TL) has been developed by using two microphones, an impedance tube and an impulse sound source as a proposed improvement to the existing procedure after Singh and Katra (1978).
Yahya, Iwan
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Effects of Electrical Stimulation with Different Impulses on Physical Characteristics of Rabbit Meat
Animal Production: Indonesian Journal of Animal Production, 2010 Meat becoming less tender with age. One of the methods to increase the meat tenderness is by electrical simulation. The objective of this study was to investigate the effect of electrical simulation with different level of impulses on physical ...
H Yurmiati, GA Wiedy, S Kusmajadi
doaj
Seasonal Influences on the Impulse Characteristics of Grounding Systems for Tropical Countries
Energies, 2019 One of the most important parameters of the performance of grounding systems is the soil resistivity. As generally known, the soil resistivity changes seasonally, hence the performance of grounding systems, at DC and under high impulse conditions.
Muhd Shahirad Reffin +6 more
doaj +1 more source