Results 41 to 50 of about 87,940 (265)

Frontal dysfunctions of impulse control – a systematic review in borderline personality disorder and attention deficit hyperactivity disorder

open access: yesFrontiers in Human Neuroscience, 2014
Disorders such as borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD) are characterized by impulsive behaviors. Impulsivity as used in clinical terms is very broadly defined and entails different categories including ...
Alexandra eSebastian   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Synergistic Effects of Depression and Poor Impulse Control on Physical Partner Violence; A National Study in the United States [PDF]

open access: yesInternational Journal of Epidemiologic Research, 2017
Background and aims: Although major depressive disorder (MDD) also increases the risk of intimate partner violence (IPV) perpetration, poor mental health has been mostly conceptualized as a consequence of IPV victimization rather than a risk factor for ...
Shervin Assari
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

WARS2-Associated Neuropsychiatric Phenotype in Childhood: A Case-Based Review

open access: yesAnnals of Indian Academy of Neurology
Mitochondrial WARS2-related disorders are known to exhibit a broad phenotypic spectrum, ranging from infantile-onset epilepsy syndromes to hyperkinetic movement disorders. We report a case of an 11-year-old male who presented with tremors, dystonic falls,
Shabnam Kalita   +3 more
doaj   +1 more source

Development and automation of a test of impulse control in zebrafish

open access: yesFrontiers in Systems Neuroscience, 2013
Deficits in impulse control (difficulties in inhibition of a pre-potent response) are fundamental to a number of psychiatric disorders, but the molecular and cellular basis is poorly understood.
Matthew O Parker   +6 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Decomposition Method for Finding Suboptimal Impulse Controls of Electric Drives of Manipulation Robots

open access: yesИзвестия Иркутского государственного университета: Серия "Математика"
Modeling the motion of a manipulation robot with a large number of degrees of freedom leads to complex nonlinear control systems of high-dimensional differential equations.
Yu. F. Dolgii, A.N. Sesekin
doaj   +1 more source

Philosophy of life in successful community

open access: yesФілософія освіти, 2019
Historical experience and scientific researches witness that both an individual’s life success and a country’s prosperity and the living standard of population depend not on the quality of education itself, but on its effectiveness.
Valentyn Mychailovych Pomohaibo
doaj   +1 more source

Invariance for impulsive control systems [PDF]

open access: yes42nd IEEE International Conference on Decision and Control (IEEE Cat. No.03CH37475), 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Valeriano Antunes de Oliveira   +2 more
openaire   +3 more sources

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