Results 51 to 60 of about 9,674,234 (294)
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Journal of Community Nursing and Primary CareBackground: Internet addiction has emerged as a growing behavioral concern among adolescents, often associated with emotional dysregulation and psychological distress.
Aaras Sharm, Priya Kappor
doaj +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Impulse ageing of polymeric materials
, 2011 Impulse over-voltage is a common phenomenon in electric power systems. A switching impulse is created by a switching surge or local fault while a lightning impulse is due to direct lightning strike to high voltage plant such as an overhead line.
Dao, Ngoc Long
core +1 more source
Risk and maintenance factors in body‐focused repetitive behaviours
JEADV Clinical PracticeBackground Body‐focused repetitive behaviours (BFRBs), such as skin picking and trichotillomania, are conditions at the interface of dermatology and psychiatry.
Steffen Moritz +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Известия Иркутского государственного университета: Серия "Математика"Modeling the motion of a manipulation robot with a large number of degrees of freedom leads to complex nonlinear control systems of high-dimensional differential equations.
Yu. F. Dolgii, A.N. Sesekin
doaj +1 more source
Philosophy of life in successful community
Філософія освіти, 2019 Historical experience and scientific researches witness that both an individual’s life success and a country’s prosperity and the living standard of population depend not on the quality of education itself, but on its effectiveness.
Valentyn Mychailovych Pomohaibo
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Synergistic Effects of Depression and Poor Impulse Control on Physical Partner Violence; A National Study in the United States [PDF]
International Journal of Epidemiologic Research, 2017 Background and aims: Although major depressive disorder (MDD) also increases the risk of intimate partner violence (IPV) perpetration, poor mental health has been mostly conceptualized as a consequence of IPV victimization rather than a risk factor for ...
Shervin Assari
doaj +1 more source