Results 51 to 60 of about 87,940 (265)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Exposing an “Intangible” Cognitive Skill Among Collegiate Football Players: II. Enhanced Response Impulse Control

Frontiers in Psychology, 2018
American football is played in a dynamic environment that places considerable demands on a player’s ability to make fast, precise reactions while controlling premature, impulsive reactions to spatial misinformation.
Theodore R. Bashore, Theodore R. Bashore, Brandon Ally, Nelleke C. van Wouwe, Joseph S. Neimat, Wery P. M. van den Wildenberg, Scott A. Wylie   +6 more
doaj   +1 more source

Optimal Exploitation of a General Renewable Natural Resource under State and Delay Constraints

Mathematics, 2020
In this work, we study an optimization problem arising in the management of a natural resource over an infinite time horizon. The resource is assumed to evolve according to a logistic stochastic differential equation.
M’hamed Gaïgi, Idris Kharroubi, Thomas Lim   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Impulse Control Disorders are Associated with Multiple Psychiatric Symptoms in Parkinson's Disease

Journal of Parkinson’s Disease, 2014
Background: Impulse control disorders can have serious adverse consequences to the life of a patient with Parkinson's disease. Although impulse control disorders are common, a possible psychiatric comorbidity has not been fully characterized.
Elina Jaakkola, Valtteri Kaasinen, Chiara Siri, Kirsti Martikainen, Roberto Cilia, Solja Niemelä, Juho Joutsa   +6 more
doaj   +1 more source

Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field

Frontiers in Human Neuroscience, 2017
Impulsivity is a personality trait of clinical importance. Extant research focuses on fronto-striatal mechanisms of impulsivity and how executive functions are compromised in impulsive individuals.
Jaime S. Ide, Hsiang C. Tung, Cheng-Ta Yang, Yuan-Chi Tseng, Chiang-Shan R. Li, Chiang-Shan R. Li, Chiang-Shan R. Li, Chiang-Shan R. Li   +7 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Event-Triggered Impulsive Formation Control for Cooperative Obstacle Avoidance of UAV Swarms in Tunnel Environments

Drones
UAV formation navigation in complex environments such as narrow tunnels faces multiple challenges, including obstacle avoidance, formation maintenance, and communication constraints.
Rui Hao, Wenjie Zhou, Yuanfan Wang, Yuehao Yan   +3 more
doaj   +1 more source

Dietary Long-Chain Omega-3 Fatty Acids Are Related to Impulse Control and Anterior Cingulate Function in Adolescents

Frontiers in Neuroscience, 2019
Impulse control, an emergent function modulated by the prefrontal cortex (PFC), helps to dampen risky behaviors during adolescence. Influences on PFC maturation during this period may contribute to variations in impulse control.
Valerie L. Darcey, Valerie L. Darcey, Goldie A. McQuaid, Diana H. Fishbein, John W. VanMeter   +4 more
doaj   +1 more source