Results 41 to 50 of about 116,397 (296)
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
Existence and uniqueness of solutions to impulsive fractional differential equations
Electronic Journal of Differential Equations, 2009 In this article, we establish sufficient conditions for the existence of solutions for a class of initial value problem for impulsive fractional differential equations involving the Caputo fractional derivative.
Boualem Attou Slimani, Mouffak Benchohra
doaj
MathematicsIn this paper, the impulsive conformable calculus approach is applied to the introduction of an M1 oncolytic virotherapy neural network model. The proposed model extends some existing mathematical models that describe the dynamics of the concentrations ...
Gani Stamov +2 more
doaj +1 more source
The rule of law in the function of human dignity [PDF]
NBP: Nauka, bezbednost, policija, 2019 Human dignity is the universal value of human beings. They have this value because they are potentially mindful beings. This does not mean that every man is mindful, but that every man can be mindful, and therefore dignified. It makes possible for people
Zekavica Radomir G.
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos +17 more
wiley +1 more source
Stability of Differential Equations with Random Impulses and Caputo-Type Fractional Derivatives
AxiomsIn this paper, we study nonlinear differential equations with Caputo fractional derivatives with respect to other functions and impulses. The main characteristic of the impulses is that the time between two consecutive impulsive moments is defined by ...
Snezhana Hristova +2 more
doaj +1 more source
Mathematics, 2022 The synchronization problem for impulsive fractional-order Cohen–Grossberg neural networks with generalized proportional Caputo fractional derivatives with changeable lower limit at any point of impulse is studied.
Ravi Agarwal, Snezhana Hristova
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective Pediatric rheumatologic diseases (PRDs) are characterized by high rates of anxiety and depression known to impact health‐related outcomes. We present guidance statements to assess and manage mental health concerns for youth with PRDs in pediatric rheumatology practice.
Natoshia R. Cunningham +21 more
wiley +1 more source