Results 51 to 60 of about 106,026 (301)
, 2022 In this paper, nonlinear differential equations with a generalized proportional Caputo fractional derivative and finite delay are studied in this paper. The eventual presence of impulses in the equations is considered, and the statement of initial value ...
Ravi P. Agarwal +2 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Periodic solutions for neutral functional differential equations with impulses on time scales
Electronic Journal of Differential Equations, 2012 Let $mathbb{T}$ be a periodic time scale. We use Krasnoselskii's fixed point theorem to show that the neutral functional differential equation with impulses $$displaylines{ x^{Delta}(t)=-A(t)x^sigma(t)+g^Delta(t,x(t-h(t)))+f(t,x(t),x(t-h(t))),quad ...
Yongkun Li, Xiaoyan Dou, Jianwen Zhou
doaj
Mathematics, 2019 In this paper, a class of fractional complex networks with impulses and reaction−diffusion terms is introduced and studied. Meanwhile, a class of more general network structures is considered, which consists of an instant communication topology and
Xudong Hai +3 more
doaj +1 more source
Bifurcation Analysis and Application for Impulsive Systems with Delayed Impulses [PDF]
International Journal of Bifurcation and Chaos, 2017 In this article, we present a systematic approach to bifurcation analysis of impulsive systems with autonomous or periodic right-hand sides that may exhibit delayed impulse terms. Methods include Lyapunov–Schmidt reduction and center manifold reduction.
Kevin E. M. Church, Xinzhi Liu
openaire +4 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The rule of law in the function of human dignity [PDF]
NBP: Nauka, bezbednost, policija, 2019 Human dignity is the universal value of human beings. They have this value because they are potentially mindful beings. This does not mean that every man is mindful, but that every man can be mindful, and therefore dignified. It makes possible for people
Zekavica Radomir G.
doaj
Are PIIGS so different? An empirical analysis of demand and supply shocks [PDF]
Panoeconomicus, 2017 This paper analyses responses to supply and demand shocks in PIIGS countries. We compare the results obtained for PIIGS with those of Germany and the USA, and also with those of France, which despite its government’s efforts demonstrate ...
Syssoyeva-Masson Irina +1 more
doaj +1 more source
Impulsive Reaction-Diffusion Delayed Models in Biology: Integral Manifolds Approach
Entropy, 2021 In this paper we study an impulsive delayed reaction-diffusion model applied in biology. The introduced model generalizes existing reaction-diffusion delayed epidemic models to the impulsive case.
Gani Stamov +2 more
doaj +1 more source