Results 71 to 80 of about 106,026 (301)
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Cross-generalisation of coding scheme between impulses.
, 2020 (A) Visualisation of orientation and impulse code in state space. The first dimension discriminates between impulses. The second and third dimensions code the orientation space in both impulses. (B) Trial-wise accuracy (%) of impulse decoding.
Elkan G. Akyürek (8520261) +4 more
core +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
Remarks on impulses’ dynamics in Nietzsche’s work [PDF]
, 2010 This paper intends to make evident the dynamism of the impulses according to Nietzsche’s perspectivism. We emphasized, above all, the way impulses are presented by Friedrich Nietzsche as an important key for understanding morals and life.
Machado, Bruno Martins +1 more
core +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Stability of Differential Equations with Random Impulses and Caputo-Type Fractional Derivatives
AxiomsIn this paper, we study nonlinear differential equations with Caputo fractional derivatives with respect to other functions and impulses. The main characteristic of the impulses is that the time between two consecutive impulsive moments is defined by ...
Snezhana Hristova +2 more
doaj +1 more source
, 2019 On this page you can access a short video trailer which summarizes the workshop of The Real Health Center which was realized in August 2017 in a public space in Helsinki. The clip aims to give a short, but broad view of the whole workshop.
Haapala, Sami Henrik
core
, 2017 We extend recent results on the existence of positive periodic solutions for singular ordinary differential equations. The nonlinearity and the impulses satisfy weaker conditions and we present new examples.Ministerio de Economía, Comercio y Empresa ...
Juan J. Nieto +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source