Results 51 to 60 of about 675,673 (375)
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Partial discharge behavior under operational and anomalous conditions in HVDC systems [PDF]
, 2017 Power cables undergo various types of overstressing conditions during their operation that influence the integrity of their insulation systems. This causes accelerated ageing and might lead to their premature failure in severe cases.
Azizian Fard, M. +3 more
core +3 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
On the fractional differential equations with not instantaneous impulses
Open Physics, 2016 Based on some previous works, an equivalent equations is obtained for the differential equations of fractional-orderq ∈(1, 2) with non-instantaneous impulses, which shows that there exists the general solution for this impulsive fractional-order systems.
Zhang Xianmin +5 more
doaj +1 more source
Positive periodic solutions for discrete time-delay hematopoiesis model with impulses
Open Mathematics, 2023 The present article is devoted to the positive periodic solution for impulsive discrete hematopoiesis model. This model is described by a first-order nonlinear difference equation with multiple delays and impulses.
Yan Yan
doaj +1 more source
Horizontal and vertical relations: Interrogating "in/dividualism" among Christian Bidayuhs [PDF]
, 2015 This article addresses aspects of the dividual/individualist debate by thinking through an analogous set of ideas and practices among the Bidayuh, an indigenous group of Malaysian Borneo.
Chua, L
core +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Pressure Pulses Generated by Cloud Cavitation [PDF]
, 1996 This paper describes an experimental investigation of the large unsteady and impulsive pressures which are experienced on the suction surface of both an oscillating and static hydrofoil as a result of cloud cavitation. The present experiments used piezo-
Brennen, C. E., Reisman, G. E.
core
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source