Results 61 to 70 of about 230,992 (300)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Frontiers in Genetics, 2018 The whole-genome sequences of progenies with low-density single-nucleotide polymorphism (SNP) genotypes can be imputed with high accuracy based on the deep-coverage sequences of key ancestors.
Guorong Yan +9 more
doaj +1 more source
Flexible Imputation of Missing Data
, 2018 Missingness is a commonly occurring phenomenon in many applications. Determining a suitable analytical approach in the absence of complete observations is a major focus of scientific inquiry due to the extra sophistication that arises through missing ...
H. Demirtas
semanticscholar +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
IEEE AccessRising urbanization necessitates robust air quality monitoring and prediction systems, particularly in developing nations like India, to mitigate adverse health impacts.
Routhu Srinivasa Rao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
BiologySingle-cell transcriptomics (scRNA-seq) is revolutionizing biological research, yet it faces challenges such as inefficient transcript capture and noise. To address these challenges, methods like neighbor averaging or graph diffusion are used.
Padron-Manrique Cristian +8 more
doaj +1 more source
Imputer: Sequence Modelling via Imputation and Dynamic Programming
CoRR, 2020 This paper presents the Imputer, a neural sequence model that generates output sequences iteratively via imputations. The Imputer is an iterative generative model, requiring only a constant number of generation steps independent of the number of input or output tokens. The Imputer can be trained to approximately marginalize over all possible alignments
William Chan +4 more
openaire +3 more sources
Multiply-Imputed Synthetic Data: Advice to the Imputer [PDF]
Journal of Official Statistics, 2017 Abstract Several statistical agencies have started to use multiply-imputed synthetic microdata to create public-use data in major surveys. The purpose of doing this is to protect the confidentiality of respondents’ identities and sensitive attributes, while allowing standard complete-data analyses of microdata.
Loong, Bronwyn, Rubin, Donald B
openaire +2 more sources