Results 151 to 160 of about 16,155 (248)

Prophylactic heminephrectomy for an asymptomatic, non-functioning moiety in pediatric duplex systems: is cancer prevention justified? [PDF]

Front Pediatr
Zhanghuang C, Long N, Yan B.
europepmc   +1 more source

Addressing false negatives and positives in eDNA studies

Methods in Ecology and Evolution, EarlyView.
Abstract Environmental DNA (eDNA) has revolutionized the study of ecology and biodiversity, enabling species detection without direct observation in the environment. However, the implications of detection errors, specifically false positives and false negatives, are poorly reported in eDNA studies, significantly hindering our understanding of the ...
Amal Bajaffer, Lutfi Afiq‐Rosli, Kah Kheng Lim, Sofia Frappi, Michelle‐Nicole Havlik, Diego E. Rivera Rosas, Elisa Laiolo, Carlos Angulo‐Preckler, Carlos M. Duarte   +8 more
wiley   +1 more source

Automated Detection of Carotid Artery Stenosis Using a Sensitive Accelerometer Wearable Sensor and Interpretable Machine Learning. [PDF]

Biosensors (Basel)
Majditehran H, Sang B, Desai N, Nahab F, Kvantaliani N, Blanke D, Starnes D, Christopher H, Park JW, Ayazi F.   +9 more
europepmc   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Chemical and photoinduced interstrand crosslinking of oligo DNA duplexes containing 2'-deoxythioguanosines. [PDF]

Commun Chem
Osman JA, Onizuka K, Yamano Y, Nagatsugi F.   +3 more
europepmc   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Self-Avoiding Gamma Peptide Nucleic Acids for Selective Targeting of RNA Secondary Structures. [PDF]

ACS Chem Biol
Dhami I, Thadke SA, Perera JDR, Batwal R, Zheng E, Thrikawala SW, Aryal B, Ly DH.   +7 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

An antibody uniquely binding short 2'-O-methyl RNA oligonucleotide duplexes: formation and recognition of target duplexes on cell surfaces. [PDF]

Front Immunol
Dunn IS, Lawler MM, Fagundes L, Simoes Junior M, Mangold A, Rinaldi D, Rose LB, Kurnick JT.   +7 more
europepmc   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source