Results 81 to 90 of about 115,317,412 (279)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Opportunistic Resource Scheduling for LTE-Unlicensed With Hybrid Communications Modes

IEEE Access, 2018
The rapidly increasing amounts of mobile traffic have brought new challenges on the limited spectrum resource. LTE on the unlicensed band, namely, LTE-U, under the carrier aggregation technology has been considered as a potential solution to handle the ...
Xiaoge Huang, Chunyan Cao, Yangyang Li, Qianbin Chen   +3 more
doaj   +1 more source

Self‐interference cancellation using dmrs‐based power estimation for in‐band full‐duplex transmission

Electronics Letters, 2023
This letter presents an improved Self‐Interference Cancellation (SIC) receiver with Demodulation Reference Signal (DMRS)‐based power estimation for In‐band Full‐duplex (IBFD) transmission.
J. K. Kim
doaj   +1 more source

Development of highly flexible broadband networks incorporating wavelength division multiplexing and sub-carrier division multiplexing in a hybrid radio/fiber distribution system [PDF]

, 2003
A radio over fiber distribution system incorporating both SCM and WDM technologies is presented. The SCM signal contains five 155 Mbit/s data channels, centered around 18.5 GHz with 450 MHz spacing. This signal is directly modulated onto three high-speed
Anandarajah, Prince M., Barry, Liam P., Kaszubowska-Anandarajah, Aleksandra, L.P. Barry, Kaszubowska, P. Anandarajah   +5 more
core   +2 more sources

Ductile B2 Intermetallics‐Driven Strength‐Ductility Synergy in Heterolaminated Multi‐Principal Element Alloys

Advanced Science, EarlyView.
Intrinsic phase toughening transforms a brittle B2 intermetallic into a plastically deformable, load‐bearing phase, while a heterogeneous laminated architecture suppresses strain localization and interface cracking. The synergy between ductile intermetallics and mesoscale heterogeneity establishes a general design strategy for breaking the long ...
Lu Yang, Feilong Jiang, Qiming Zhuang, Dingshan Liang, Jiasi Luo, Kangjie Chu, Junhua Luan, Zengbao Jiao, Robert O. Ritchie, Fuzeng Ren   +9 more
wiley   +1 more source

Minimizing Completion Time in Wireless Networks With In-Band Full Duplex Links

IEEE Access, 2018
One approach to improve network capacity in future wireless networks is to deploy access points (APs) in a dense manner and employ a controller to manage these APs.
Yifei Ren, Kwan-Wu Chin, Sieteng Soh
doaj   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Machine Learning of Temperature‐Dependent Chemical Kinetics Using Parallel Droplet Microreactors

Advanced Science, EarlyView.
An integrated droplet microfluidics and machine learning framework enables high‐throughput characterization of temperature‐dependent reaction kinetics. Time‐resolved measurements from thousands of droplets train Neural ODE models that accurately predict nonlinear reaction dynamics across diverse thermal environments, bridging large‐scale ...
Mamoru Saita, Yutaka Hori
wiley   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source