Results 71 to 80 of about 436,973 (257)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Research of temperature monitoring system for cable joint based on temperature field

Gong-kuang zidonghua, 2013
In view of problem that core temperature of cable joint cannot be measured directly, the paper applied finite element method to establish a model of steady temperature field distribution of cable joint, used ANSYS software to simulate and analyze the ...
HU Wan-qing, HU Qing-yi, LIN Xue, LIN Shan-ming   +3 more
doaj  

Research Status and Suggestions of Nuclear Reactor Online Core Monitoring System

Yuanzineng kexue jishu
The online core monitoring system (CMS) is a crucial system for ensuring the safe operation of nuclear power plants. Its primary function is to real-time monitor the key parameter changes within the reactor core, in order to timely detect potential ...
LI Jinggang, LI Wenhuai, ZHANG Xiangju, WANG Junling, WANG Ting, LU Haoliang, PENG Sitao
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Uncertainty Quantification in Core Power Monitoring for VVER-440 Reactors Using the BEACON Core Monitoring System

Conference paper presented at PHYSOR 2026 - The International Conference on Physics of Reactors. Published in Proceedings of PHYSOR 2026 International Conference. ISBN: 979-12-81583-46-7. Conference website: https://www.physor2026.org/. Session: R08. Core Monitoring and Reactor Control. Paper ID: 638.
D. Salazar, M. Boychenko, A. Giho, B. Frank   +3 more
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Online Intelligent Monitoring System and Key Technologies for Dam Operation Safety

Advances in Civil Engineering
To realize the comprehensive intelligent upgrade of the Three Gorges Dam safety intelligent monitoring system (IMS), we focus on three core pillars real-time information processing, professional analytical evaluation, and digital management control ...
Shuangping Li, Bin Zhang, Guangqin Tong, Yonghua Li, Zuqiang Liu, Bo Shi, Jun Geng, Dingming Liu, Huawei Wang, Qingsong Ai, Jianxin Ding, Zheng Gan   +11 more
doaj   +1 more source

Design of cloud platform alert monitoring and automatic analysis system based on random forest algorithm

Array
To address the issue of alert information overload in cloud platform monitoring, where unnecessary or duplicate alerts hinder the rapid identification of problem sources by operation and maintenance personnel, an automatic analysis system for cloud ...
Bokai Li, Mingkang Guo, Yongli Jia, Tianzi Zeng, Xiaojing Liu   +4 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source