Results 141 to 150 of about 926,981 (345)

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Life after Stroke: A Comparative Study

, 2012
Stroke is a chronic illness and is the leading cause of disability globally in the adult population. The effects of stroke are wide ranging and impact on the stroke survivor’s daily functioning and quality of life.
Thomson, Kirstin Marie
core  

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Intravenous Thrombolysis in Posterior versus Anterior Circulation Stroke: Clinical Outcome Differs Only in Patients with Large Vessel Occlusion

Biomedicines
The safety and efficacy of intravenous thrombolysis (IVT) are well established in anterior circulation stroke (ACS) but are much less clear for posterior circulation stroke (PCS).
Simona Halúsková, Roman Herzig, Robert Mikulík, Silvie Bělašková, Martin Reiser, Lubomír Jurák, Daniel Václavík, Michal Bar, Lukáš Klečka, Tomáš Řepík, Vladimír Šigut, Aleš Tomek, David Hlinovský, Daniel Šaňák, Oldřich Vyšata, Martin Vališ, on behalf of the Czech SITS Investigators   +16 more
doaj   +1 more source

Health state descriptions to elicit stroke values: do they reflect patient experience of stroke?

, 2014
Background - To explore whether stroke health state descriptions used in preference elicitation studies reflect patients’ experiences by comparing published descriptions with qualitative studies exploring patients’ lived experience.
Thomson, Richard G., Mabel L S Lie, Gary A Ford, Thomson, Richard G, Ford, Gary A, Peter McMeekin, Murtagh, Madeleine J, Gray, Joanne, Ford, Gary A., Joanne Gray, Lie, Mabel L S, Richard G Thomson, Murtagh, Madeleine J., McMeekin, Peter, Lie, Mabel L. S., Madeleine J Murtagh   +15 more
core   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases

Communications Biology
Circulating cytokines orchestrate immune reactions and are promising drug targets for immune-mediated and inflammatory diseases. Exploring the genetic architecture of circulating cytokine levels could yield key insights into causal mediators of human ...
Marek J. Konieczny, Murad Omarov, Lanyue Zhang, Rainer Malik, Tom G. Richardson, Sebastian-Edgar Baumeister, Jürgen Bernhagen, Martin Dichgans, Marios K. Georgakis   +8 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Impact on Clinical and Cost Outcomes of a Centralized Approach to Acute Stroke Care in London: A Comparative Effectiveness Before and After Model

, 2013
Background In July 2010 a new multiple hub-and-spoke model for acute stroke care was implemented across the whole of London, UK, with continuous specialist care during the first 72 hours provided at 8 hyper-acute stroke units (HASUs) compared to the ...
Rachael Maree Hunter (393680), Mountford, James, Davie, C, Stephen Morris (324510), Stephen Morris, Thompson, A, Hilary Walker, Quoraishi, S, Bikash Dewan (440513), Thompson, Alan, Sadik Quoraishi, Mountford, J, Charles Davie (440505), John Deanfield (256140), Deanfield, John, Lee Schwamm, Minesh Mistry (440514), Kerry Thompson (440512), Anthony Rudd (440506), Morris, Stephen, Dewan, Bikash, Neil Thomson, Walker, H, Walker, Hilary, John Deanfield, James Mountford (440510), James Mountford, Schwamm, L, Neil Thomson (440509), Lee Schwamm (440511), Hunter, Rachael Maree, Schwamm, Lee, Minesh Mistry, Davie, Charles, Quoraishi, Sadik, Rudd, A, Charles Davie, Anthony Rudd, Thomson, N, Bikash Dewan, Mistry, Minesh, Rachael Maree Hunter, Thomson, Neil, Hilary Walker (440508), Deanfield, J, Morris, S, Thompson, K, Hunter, Rachael M., Dewan, B, Thompson, Kerry, Sadik Quoraishi (440515), Rudd, Anthony, Hunter, RM, Mistry, M, Alan Thompson, Kerry Thompson, Alan Thompson (440507)   +56 more
core   +1 more source