Results 71 to 80 of about 120,659,477 (285)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Distributed computing paradigm for target classification in sensor networks

, 2006
In this paper, we develop an energy and bandwidth efficient approach for target classification in sensor networks. Instead of adopting decision fusion to reduce network traffic as some recent research, we try to realize energy efficient target ...
Huang Y(黄艳), Yu HB(于海斌), Zeng P(曾鹏)   +2 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

On Distributed Sensor Fusion in Batteryless Intermittent Networks

, 2019
15th Annual International Conference on Distributed Computing in Sensor Systems (DCOSS) -- MAY 29-31, 2019 -- GREECEYildirim, Kasim Sinan/0000-0002-9528-6923Distributed and collaborative computation has never been considered before in networks of ...
Przemyslaw Pawelczak, Kasim Sinan Yildirim, Pawelczak, Przemyslaw, Yildirim, Kasim Sinan   +3 more
core   +1 more source

A review of memristive reservoir computing for temporal data processing and sensing

InfoScience
Reservoir computing (RC) is a promising paradigm for machine learning that uses a fixed, randomly generated network, known as the reservoir, to process input data.
Yoon Ho Jang, Joon‐Kyu Han, Cheol Seong Hwang   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A utility-based adaptive sensing and multi-hop communication protocol for wireless sensor networks

, 2000
This article reports on the development of a utility-based mechanism for managing sensing and communication in cooperative multisensor networks. The specific application on which we illustrate our mechanism is that of GlacsWeb.
Rajdeep K. Dash, Martinez, Kirk, Jennings, Nick, Dash, Rajdeep, Kirk Martinez, Nicholas R. Jennings, Padhy, P, Padhy, Paritosh, Jennings, N, Paritosh Padhy, Martinez, K, Dash, R   +11 more
core   +1 more source