Results 31 to 40 of about 118,397,027 (305)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A novel model for calculating in situ stress within deep coal seams considering microstructural characteristics and its application

Meitian dizhi yu kantan
Objective Research on in situ stress serves as a bridge between geological and engineering analyses. Accurate insights into in situ stress regimes are crucial for ensuring engineering efficiency and development benefits. However, microstructures are well
Haifeng ZHAO, Hongwei SHI, Fei XIE, Chengwang WANG, Zongfei WANG, Gaojie CHEN   +5 more
doaj   +1 more source

Propagation of hydraulic fractures in bedded shale based on phase-field method

Yantu gongcheng xuebao, 2022
Accurate prediction of the propagation path of hydraulic fractures in shale plays an important role in optimizing fracturing schemes and evaluating fracturing effects.
LIU Jia 1, XUE Yi 1, GAO Feng 2, TENG Teng 3, LIANG Xin 1
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Inversion of In-situ stress field in near-fault coal mining area by coupling numerical simulation with deep learning

Geomatics, Natural Hazards & Risk
Understanding the in-situ stress distribution is crucial for coal mine production. In mining area 105 of Yuandian No. 1 Coal Mine, in-situ stress measurements were carried out using the stress relief method.
Rongqin Deng, Yuan Zhang, Dong Wu, Jiakun Lv, Yanan Jing, Zheng Zhen, Peng Shi   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

In-Situ

Formed in 2012, In-Situ is an artist led not-for-profit arts organisation based in Brierfield, Pendle, Lancashire. In-Situ openly explores the built and natural environment; how we live our lives; perceptions of the everyday, shared histories; and local
Morrison, Kerry, Titley, William David, Hartley, Paul   +2 more
core   +4 more sources