Results 51 to 60 of about 118,397,027 (305)

Characteristics of in-situ stresses and engineering stability analysis on the south section of the Bohai Strait Cross-Sea Corridor project

Dizhi lixue xuebao
Objective  The Bohai Strait Cross-Sea Corridor is an important maritime traffic project which joins the Liaodong and the Shandong peninsulas. The state of geostress is an important reference for engineering design and construction decision-making ...
QIAO Erwei, MA Xiumin, GUO Hualin, Sun Yao, JIANG Jingjie   +4 more
doaj   +1 more source

In-situ stress characteristics and rockburst tendency of surrounding rocks in the Shuiwangzhuang gold deposit, Zhaoyuan, Shandong province

Dizhi lixue xuebao, 2023
We carried out hydraulic fracturing in-situ stress measurements in an 1881-m deep borehole at the Shuiwangzhuang gold deposit and obtained the variation law of deep in-situ stress with depth in the mining area.
LIU Luyong, LI Kaizhou, WANG Nengwei, YANG Zhijie, YANG Dongming, SUN Yao   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Estimate the In-situ Earth Pressure in a Thrust Fault Zone by Vertical Cut [PDF]

, 2013
The tension crack appears at the ground surface acompanied by excavations in soils. The development of tension crack is depended upon the horizontal earth pressure exerted on the soils.
楊長義
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Influence of blast hole shape and in-situ stress on blast damage evolution in granite by numerical simulation

Frontiers in Earth Science
With the increasing development of deep underground engineering projects, under in-situ stress constraints, tunnel blasting excavation faces significant challenges in crack control.
Cunquan Wu, Fasheng Luo, Bin Li, Gaoyu Lin, Bo Hu, Xuefu Zhang, Mi Nie   +6 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Determination of In-Situ Stress and Geomechanical Properties from Borehole Deformation

Energies, 2018
This paper proposes a cost-effective technique to determine geomechanical properties and in-situ stress from borehole deformation data. In this approach, an artificial neural network (ANN) is applied to map the relationship among in-situ stress, borehole
Hong Xue Han, Shunde Yin
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source