Results 71 to 80 of about 114,629,556 (343)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Preliminary Analysis of In-Situ Stress at Mount Meager by Displacement Discontinuity Method with Topography and Tectonics Considered

Energies, 2023
Geothermal energy is one of the most stable and clean solutions to replace the traditional fossil fuel energy resource. The South Meager geothermal prospect, located in southwestern British Columbia, contains large geothermal energy resources due to ...
Yutong Chai, Zhuoheng Chen, Shunde Yin
doaj   +1 more source

In situ stress state in Mainland China [PDF]

pure and applied geophysics, 1995
In situ stress measurements are one of the important methods for studying the recent tectonic stress field and stress state. In this paper, the stress state and variation of stresses with depth in Mainland China are presented and analyzed on the basis of in situ stress data measured by both hydrofracturing and overcoring techniques.
openaire   +1 more source

Local Stress Field Correction Method Based on a Genetic Algorithm and a BP Neural Network for In Situ Stress Field Inversion

Advance in Civil Engineering, 2021
The in situ stress field is the fundamental factor causing deformation and damage in geotechnical engineering, so it is the main basis for underground engineering design and excavation.
Tianzhi Yao, Zu-Guo Mo, Li Qian, Jianhua He, Jian-Hai Zhang   +4 more
semanticscholar   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

In-situ stress characteristics and rockburst tendency of surrounding rocks in the Shuiwangzhuang gold deposit, Zhaoyuan, Shandong province

Dizhi lixue xuebao, 2023
We carried out hydraulic fracturing in-situ stress measurements in an 1881-m deep borehole at the Shuiwangzhuang gold deposit and obtained the variation law of deep in-situ stress with depth in the mining area.
LIU Luyong, LI Kaizhou, WANG Nengwei, YANG Zhijie, YANG Dongming, SUN Yao   +5 more
doaj   +1 more source

Combined finite-discrete element modelling of rock fracture and fragmentation induced by contour blasting during tunnelling with high horizontal in-situ stress

, 2020
A combined finite-discrete element method (FDEM) parallelized on the basis of GPGPU is implemented to model the rock fracture and fragmentation process and the resultant excavation damaged zone (EDZ) development induced by the controlled contour blasting,
Hao-Yu Han, D. Fukuda, Hongyuan Liu, E. F. Salmi, E. Sellers, Ting-Jin Liu, A. Chan   +6 more
semanticscholar   +1 more source

Study on the Influence of In Situ Stress Distribution on the Stability of Roadway Surrounding Rock

Advance in Civil Engineering, 2021
In order to understand the instability characteristics of surrounding rock in the process of deep roadway excavation, a three-dimensional numerical model was established by FLAC3D to systematically analyze the influence of roadway surrounding rock ...
Tao Li, Hao Gong, Guoliang Xu
semanticscholar   +1 more source

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source