Results 41 to 50 of about 114,871,075 (252)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Transient heat transfer and crust evolution during debris bed melting process in the hypothetical severe accident of HPR1000

Nuclear Engineering and Technology, 2023
In the late in-vessel phase of a nuclear reactor severe accident, the internal heat transfer and crust evolution during the debris bed melting process have important effects on the thermal load distribution along the vessel wall, and further affect the ...
Chao Lv, Gen Li, Jinchen Gao, Jinshi Wang, Junjie Yan   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Numerical simulation on heat transfer in RPV lower head corium pools

He jishu, 2022
BackgroundIn-vessel Retention (IVR) refers to the prevention of pressure vessel melt-through failure by injecting cooling water into the gap between the pressure vessel and the heat insulation layer during a serious accident in a nuclear power plant ...
ZHU Guangyu, MIN Jinkun, JING Jianping, WANG Kunpeng, LIU Fudong   +4 more
doaj   +1 more source

Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]

, 2013
We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Di Qin (107446), Seungmin Lee (68256), Qin, Di, Christian Kupatt (402864), Rabea Hinkel, Trenkwalder, Teresa, Rabea Hinkel (402865), Deindl, Elisabeth, Chillo, Omary, Teresa Trenkwalder (402861), Seungmin Lee, Christian Kupatt, Omary Chillo, Lee, Seungmin, Omary Chillo (402862), Kupatt, Christian, Elisabeth Deindl (402863), Di Qin, Hinkel, Rabea, Teresa Trenkwalder, Elisabeth Deindl   +20 more
core   +2 more sources

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Modelling of Severe Accident and In-Vessel Melt Retention Possibilities in BWR Type Reactor

Science and Technology of Nuclear Installations, 2018
One of the severe accident management strategies for nuclear reactors is the melted corium retention inside the reactor pressure vessel. The work presented in this article investigates the application of in-vessel retention (IVR) severe accident ...
Mindaugas Valinčius, Tadas Kaliatka, Algirdas Kaliatka, Eugenijus Ušpuras   +3 more
doaj   +1 more source

A preliminary evaluation of unprotected loss-of-flow accident for a prototype fast-breeder reactor

Nuclear Engineering and Technology, 2015
In the original licensing application for the prototype fast-breeder reactor, MONJU, the event progression during an unprotected loss of flow (ULOF), which is one of the technically inconceivable events postulated beyond design basis, was evaluated ...
Tohru Suzuki, Yoshiharu Tobita, Kenichi Kawada, Hirotaka Tagami, Joji Sogabe, Kenichi Matsuba, Kei Ito, Hiroyuki Ohshima   +7 more
doaj   +1 more source

Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification [PDF]

, 2006
—We present a method for automated segmentation of the vasculature in retinal images. The method produces segmentations by classifying each image pixel as vessel or nonvessel, based on the pixel’s feature vector. Feature vectors are composed of the pixel’
Michael J. Cree, João V. B. Soares, Herbert F. Jelinek, Cesar, R.M., Jr., Jorge J. G. Le, Senior Member, Roberto M. Cesar, Jelinek, H.F., Soares, J.V.B., Leandro, J.J.G., Cree, Michael J.   +10 more
core   +1 more source