Results 111 to 120 of about 118,893,353 (307)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Integrated Study on the Etiology and In-Vitro Fungicidal Management of False Smut Disease in Rice

Journal of Applied Research in Plant Sciences
Rice is the second most valuable food grain and cash crop in Pakistan after wheat and cotton, serving as a vital source of food and income across Asia.
Mehrab Khan , Zubair Ahmed Nizamani, Gul Bahar Pussio, Hamal Rahim   +3 more
doaj   +1 more source

SOPHY project: an observational study of vaginal pH, lifestyle and correct intimate hygiene in women of different ages and in different physiopathological conditions. Part II.

, 2008
AIM: The first part of the Study on pH and Hygiene (SOPHY) evidenced some interesting correlations between clothing and the frequency of candidosis and bacterial vaginosis, between vaginal pH and satisfactory sexual activity, and between education and ...
in SOPHY Study Group, Guaschino S, Benvenuti C, BONACCORSI, Gloria   +2 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes

International Journal of Nanomedicine, 2010
Preety Panwar1, Bhumika Pandey1, P C Lakhera2, K P Singh11Biophysics and Nanotechnology Research Laboratory, CBSH, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India; 2Department of Biotechnology, H.N.B. Garhwal University,
Preety Panwar, Bhumika Pandey, P C Lakhera, et al   +3 more
doaj  

Mechanism-based inhibition of squalene epoxidase by phenothiazines for lipid metabolism disruption using repurposed antipsychotic drugs

Scientific Reports
Squalene epoxidase (SQLE) is a crucial enzyme in the cholesterol-biosynthesis pathway and a promising target for treating cholesterol-related disorders.
Emadeldin M. Kamel, Noha A. Ahmed, Faris F. Aba Alkhayl, May Bin-Jumah, Naif G. Altoom, Fahad M. Alshabrmi, Saleh Maodaa, Al Mokhtar Lamsabhi   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Oxygen tension affects histone remodeling of in vitro-produced embryos in a bovine model

, 2015
In vitro production of bovine embryos is a biotechnology of great economic impact. Epigenetic processes, such as histone remodeling, control gene expression and are essential for proper embryo development.
Gaspar, Roberta C., Garcia, Joaquim M., Vantini, Roberta [UNESP], Penteado, Joao C. T. [UNESP], Rocha, Carlos V. da, Correa, Carolina A. P., del Collado, Maite, Vantini, Roberta, Correa, Carolina A. P. [UNESP], del Collado, Maite [UNESP], Arnold, Daniel R., Lopes, Flavia L., Rocha, Carlos V. da [UNESP], Lopes, Flavia L. [UNESP], Penteado, Joao C. T., Gaspar, Roberta C. [UNESP], Garcia, Joaquim M. [UNESP]   +16 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Direct comparison between in vivo and in vitro microsized particle phagocytosis assays in Drosophila melanogaster

, 2018
The effects of micro and nanoparticles on the innate immune system have been widely investigated and a general lack of agreement between in vivo and in vitro assays has been observed.
Prinz, C. N.,, Abariute, L.,, Häcker, U.,, Lund University., Adolfsson, K.,, Dabkowska, A. P.,, Schneider, M.,   +6 more
core   +1 more source