Results 121 to 130 of about 118,893,353 (307)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Comparative study of the in vitro and in vivo characteristics of cationic and neutral liposomes

International Journal of Nanomedicine, 2011
Wei Zhao, Song Zhuang, Xian-Rong QiDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, People's Republic of ChinaAbstract: Neutral liposomes (NLP) exhibit preferential localization in solid tumors based on ...
Zhao W, Zhuang S, Qi XR
doaj  

In vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug

International Journal of Nanomedicine, 2020
Akhtar Rasul,1,* Muhammad Imran Khan,2,* Mujeeb Ur Rehman,1,* Ghulam Abbas,1,* Nosheen Aslam,3,* Shabbir Ahmad,4,* Khizar Abbas,5,* Pervaiz Akhtar Shah,6,* Muhammad Iqbal,7,* Ali Mohammad Ahmed Al Subari,6,* Talal Shaheer,8,* Shahid Shah9,* 1Department ...
Rasul A, Imran Khan M, Rehman MU, Abbas G, Aslam N, Ahmad S, Abbas K, Akhtar Shah P, Iqbal M, Ahmed Al Subari AM, Shaheer T, Shah S   +11 more
doaj  

The impact of bisphenol AF on skeletal muscle function and differentiation in vitro

Various environmental chemicals have been identified as contributors to metabolic diseases. Bisphenol AF (BPAF), a substitute for bisphenol A, has been associated with changes in glucose metabolism and incidence of type 2 diabetes mellitus in humans ...
Munic Kos, Vesna,, Tzioufa, Foteini, Westerblad, Håkan, Westerblad, H,, Bruton, Joseph,, Cui, M,, Cui, Minying, Cui, Minying,, Bruton, J,, Tzioufa, F, Bruton, Joseph, Tzioufa, Foteini,, Westerblad, Håkan,, Kos, VM, Munic Kos, Vesna   +14 more
core   +1 more source

Induced polyploidization increases 20-hydroxyecdysone content, in vitro photoautotrophic growth, and ex vitro biomass accumulation in Pfaffia glomerata (Spreng.) Pedersen

, 2016
The present study aimed to verify the effects of induced polyploidization on Pfaffia glomerata regarding its 20-hydroxyecdysone (20E) production both in vitro and under greenhouse conditions, its in vitro photoautotrophic potential, and its ex vitro ...
Otoni, Wagner Campos, Corrêa, João Paulo Oliveira, Saldanha, Cleber Witt, Freitas, Débora Márcia Silva, Pinheiro, Marcos Vinícius Marques, Batista, Diego Silva, Cruz, Ana Cláudia Ferreira da, Vital, Camilo Elber, DaMatta, Fábio Murilo, Notini, Marcela Morato   +9 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evaluation of optimum conditions for pachyman encapsulated in poly(D,L-lactic acid) nanospheres by response surface methodology and results of a related in vitro study

International Journal of Nanomedicine, 2016
Sisi Zheng, Li Luo, Ruonan Bo, Zhenguang Liu, Jie Xing, Yale Niu, Yuanliang Hu, Jiaguo Liu, Deyun Wang Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s ...
Zheng S, Luo L, Bo R, Liu Z, Xing J, Niu Y, Hu Y, Liu J, Wang D   +8 more
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source