Results 41 to 50 of about 103,882,593 (296)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Cleaning of water-gilded surfaces using hydro- and solvent-gels [PDF]

open access: yes, 2013
This paper describes the implementation of three customized gels on a 19th century panel painting for the removal of its degraded natural resin varnish from a water-gilded surface and a complex solvent-sensitive stratigraphic construction over the gilded
Bakalarou, Angeliki   +1 more
core  

Development of Biological Risk Assessment Protocols for Evaluating the Risks of In-Water Cleaning of Hull-Fouling Organisms

open access: yesJournal of Marine Science and Engineering
Herein, we evaluate the scientific basis for managing hull fouling of ships entering Korean ports, diagnose biological risks that may occur when in-water cleaning (IWC) systems remove hull fouling, and present a protocol for evaluating these risks (the ...
Bonggil Hyun   +10 more
doaj   +1 more source

Soiling and Cleaning of Polymer Film Solar Reflectors

open access: yesEnergies, 2016
This paper describes the accelerated ageing of commercially available silvered polymer film by contact cleaning using brushes and water in the presence of soiling created by dust and sand particles.
Christopher Sansom   +5 more
doaj   +1 more source

Evaluation of Anode Water Electrolyzed with Anion Exchange Membrane for Cleaning EUV Semiconductor

open access: yesECS Advances, 2023
Electrically nonconducting UPW was electrolyzed without electrolyte through anion exchange membrane for evaluating applicability to EUV semiconductor cleaning. Produced anode water held positive ORP up to 900 mV, which is very oxidative.
Hyungwon Kim   +6 more
doaj   +1 more source

Clean Water User Behavior for Clean Water Savings in Topoyo Mamuju

open access: yesIOP Conference Series: Earth and Environmental Science, 2021
Abstract The purpose of this study is to analyze people’s behavior in using clean water based on their water source and the factors that influence that behavior. This research method through data collection is done by observing the level of education, type of work, income level, number of people, analysis of the relationship between ...
D Musa, S Trisutomo, A Akil
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Measuring the effect of enhanced cleaning in a UK hospital : a prospective cross-over study [PDF]

open access: yes, 2009
Increasing hospital-acquired infections have generated much attention over the last decade. There is evidence that hygienic cleaning has a role in the control of hospital-acquired infections.
Dancer, Stephanie J.   +4 more
core   +4 more sources

Biofilms associated with ship submerged surfaces: implications for ship biofouling management and the environment

open access: yesFrontiers in Marine Science, 2023
Biofouling (including initial microbial biofilms) of submerged ship surfaces can directly impact vessel operations, leading to increases in fuel usage, greenhouse gas emissions, and the likelihood of non-indigenous species (NIS) transfer and impacts ...
Eugene Georgiades   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy