Results 151 to 160 of about 700,727 (353)

Generation of virtual patients for in silico cardiomyopathies drug development

, 2019
Vasileios C. Pezoulas, Nikolaos S. Tachos, Dimitrios I. Fotiadis   +2 more
openalex   +1 more source

Three-dimensional micro-structurally informed in silico myocardium -- towards virtual imaging trials in cardiac diffusion weighted MRI [PDF]

, 2022
Mojtaba Lashgari, Nishant Ravikumar, Irvin Teh, Jing‐Rebecca Li, David L. Buckley, Jürgen E. Schneider, Alejandro F. Frangi   +6 more
openalex   +1 more source

Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis

Advanced Science, EarlyView.
This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu, Kexing Li, Yuge Wang, Hongyu Li, Hongyu Zhao   +4 more
wiley   +1 more source

Multi- e GO: An in silico lens to look into protein aggregation kinetics at atomic resolution

, 2022
Emanuele Scalone, Luca Broggini, Cristina Visentin, Davide Erba, Fran Bačić Toplek, Kaliroi Peqini, Sara Pellegrino, Stéfano Ricagno, Cristina Paissoni, Carlo Camilloni   +9 more
openalex   +2 more sources

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Peer Review #1 of "Challenging a bioinformatic tool’s ability to detect microbial contaminants using in silico whole genome sequencing data (v0.2)"

, 2017
S Kumar
openalex   +1 more source

Radiation effects on silicon Summary report 1 Nov. 1965 - 20 Apr. 1967 [PDF]

Radiation-induced displacement effects measured in n and p type, low and high resistivity ...
Horiye, H., Naber, J. A., Wikner, E. G.
core   +1 more source

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Correction: Global reactivity models are impactful in industrial synthesis applications

Journal of Cheminformatics, 2023
Paulo Neves, Kelly McClure, Jonas Verhoeven, Natalia Dyubankova, Ramil Nugmanov, Andrey Gedich, Sairam Menon, Zhicai Shi, Jörg K. Wegner   +8 more
doaj   +1 more source