Results 161 to 170 of about 423,064 (316)
Análise da atividade in silico e in vitro da quercetina contra Trypanosoma cruzi
, 2019 MonografiaThe present study aimed to analyze the in silico and in vitro activity of Quercetin against Trypanosoma cruzi, Chagas disease parasite, and specifically the focus are: to analyze in silico the mechanisms of interaction of Quercetin with T ...
Santos, Allen Karlos Gomes dos
core
Advanced Science, EarlyView.Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source
A system for managing data provenance in in silico experiments
, 2011 In silico experiments use computers or computer simulation to speed up the rate at which scientific discoveries are made. However, the voluminous amounts of data generated in such experiments is often recorded in an ad hoc manner without regard to ...
Atkinson, IM +4 more
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Advanced Science, EarlyView.A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa +8 more
wiley +1 more source
Advanced Science, EarlyView.TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang +18 more
wiley +1 more source
Background: Malaria remains a significant global health burden, particularly in sub-Saharan Africa, accounting for high rates of illness and death. The growing resistance to frontline antimalarial therapies underscores the urgent need for novel drug ...
Gbolahan O. Oduselu +5 more
core +1 more source
Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils
Advanced Science, EarlyView.We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr +19 more
wiley +1 more source
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source
Establishing In-silico Credibility of Patient-Specific Finite-Element Model in a Virtual Cohort
The feasibility of transcatheter aortic valve implantation (TAVI) has been investigated by in-silico modeling to assist clinicians in the pre-operative planning of the device implantation.
Catalano C. +8 more
core +1 more source
Advanced Science, EarlyView.CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng +16 more
wiley +1 more source